DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and CG10960

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	151/535 - (28%)
Similarity:	245/535 - (45%)	Gaps:	74/535 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QNGSESNGKQ-ARIVSGLDRLLKTPPPGEQTRAVRR--------------QVIAVILANVGVFST 59
            :||::...:| .:||...|....:..|.:|...:..              |.:|.:.|..|.|:.
  Fly    33 ENGAKYGSRQPVKIVKASDNGRTSSTPHDQENLLGNMVHTSTSNNSQKWPQYVAALAAAGGAFAA 97

  Fly    60 GMTLAMPTATLHQLKDTTE----PVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIV 120
            |..|...:....::.|..|    ||  :..|.||..|...|.|....:..|||::.||||.:::.
  Fly    98 GTVLGWTSPAETEIVDRGEGYDFPV--DKDQFSWVGSAMTLGAACVCIPIGFLINMIGRKWTMLF 160

  Fly   121 LNVLIILAWILLATPSESDQNAFFW-----QLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGS 180
            |.:..||.|.:|           .|     .|..|||:||:..|.......:|..||:..:.||:
  Fly   161 LVLPFILGWTML-----------IWAVNVSMLYASRFILGIAGGAFCVTAPMYTGEIAQKEIRGT 214

  Fly   181 LILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLCVLPL---------PESHCWLL 236
            |.....:.:..||..:|.:|..:: .|.|  .|.||        :|||         |||..:|:
  Fly   215 LGSFFQLMITIGILFVYAVGAGVK-IFWL--SIICG--------ILPLIFGAIFFFMPESPTYLV 268

  Fly   237 SKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHEPEVYKPLV 301
            ||.|...|.:|:.:.||.....|   |::.|     .:...:...|.|.:.|..|:.|...|.|.
  Fly   269 SKDRSENAIKSIQWLRGKEYDYE---PELAE-----LRETDRETKANKVNVWAALNRPVTRKALA 325

  Fly   302 ILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRR--- 363
            |.|.|..|||:.||..||.:|.:|..||...|:.....:|||:.:::.|.....:::..|||
  Fly   326 ISMGLMFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILL 390

  Fly   364 -RAGI---ISTLGMSVCMFLLAGHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMISELFP 424
             .:||   |||..:.| .|.|......::: .:.:|||.::..||::.::|...:|:.|:.|||.
  Fly   391 LASGISMAISTTAIGV-YFFLQKQDAAQVV-SLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFA 453

  Fly   425 QKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTL 489
            ..::|.|..|.......::|||.||:..:.:.||:...|.:|..:.:..:||||.|:|||:.::|
  Fly   454 TDIKGFAGSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSL 518

  Fly   490 LEIEEQFRSGRSKSQ 504
            .||:::....||..|
  Fly   519 NEIQQELAGNRSTPQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	130/454 (29%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	135/460 (29%)
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	111/390 (28%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	123/423 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	7	6.800