DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and CG6484

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	125/487 - (25%)
Similarity:	226/487 - (46%)	Gaps:	50/487 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTE---PVHLNDSQASWFASVNALSAPIGG 102
            :|..|.||.:.|:.|....|.::...:...:.:...||   |:  :.||..|.:|:..|.|.:..
  Fly     5 SVLPQYIAGLSASFGALCMGASIGWSSPVENMITVNTEYGFPI--SSSQFGWVSSLLTLGATVIC 67

  Fly   103 LLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGV 167
            :..||.:|.|||:.:::.|....::.|:|:.....      ...|...||:||:..|.......:
  Fly    68 IPIGFAIDWIGRRPTMLALIPPYMVGWVLMLFAKN------VTMLYFGRFILGMCGGAFCVTAPM 126

  Fly   168 YAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLC-VLP---- 227
            |..||:....||::.....:.:..|  :||  ||.:.....|:.        :.:|| :||
  Fly   127 YCTEITATALRGTIGSFFQLLIVSG--VLY--GYLVGAFLPLLT--------INILCAILPVIFA 179

  Fly   228 -----LPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESF 287
                 :|||..:|..|.|..:|.::|.:.||.:...:....::|||   .||.:......:..|
  Fly   180 IIHFFMPESPVYLAMKGRNDDAAKALQWLRGKDADIDDELKEILEE---SQKQIDMPQVNILSS- 240

  Fly   288 WRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCP 352
               |..|.|.|.|.|.:.|..|||.|||..|:.::..|.::.|.:|......::||:.::.:|..
  Fly   241 ---LRRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQVTSTLV 302

  Fly   353 MGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQIE-----ILKEVPYLPVVAIVGFIVLSTLGLY 412
            ...|::..|||...:||.:.|:|...|:..:.|::     .:....:||:.:|..||:..::|..
  Fly   303 AVAIIDKAGRRILLLISGVLMAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIFFSIGFG 367

  Fly   413 TLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFV 477
            .:|:.:::|||.:.|:..|..:........:|||...:|.:|..:|....|.||..:|:.|..:.
  Fly   368 PVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAVIAFFYS 432

  Fly   478 YLALPETRRRTLLEIEEQFRSGR-----SKSQ 504
            ...:|||:.:|::||::....|:     .|||
  Fly   433 LFFVPETKGKTIIEIQDLLSGGKGVKSDDKSQ 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	111/447 (25%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	115/453 (25%)
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	117/463 (25%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	111/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	7	6.800