DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and CG4607

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	224/499 - (44%)
Similarity:	329/499 - (65%)	Gaps:	7/499 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPVHLNDSQASWFA 91
            |...|..|.||...||.||.:.|.|.|.||..:||.::||..||:||.|.|:|..||..::||||
  Fly    27 DSHAKEKPLGEGRLAVLRQELMVFLGNSGVLGSGMVVSMPAVTLNQLHDETQPFWLNKDESSWFA 91

  Fly    92 SVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATP-SESDQNAFFWQLIVSRFMLG 155
            |:..::.|:||||..:.|||||||.::::.|::.::.||||.|. ..||::..::|:::.|...|
  Fly    92 SIQNMACPLGGLLVSYFLDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGG 156

  Fly   156 VGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLV 220
            :.:|:..:|.|||:||||:||.||.||||||:.:|.||.::|.:||.||.:.:||..|.|.|||.
  Fly   157 IMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIRHNIQLIFGISCCYQLA 221

  Fly   221 ALLCVLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRN-TAVK 284
            |.|.|.|:|||..|||::.:...|::||.||||..|.:....|:...|...:::.....| ||..
  Fly   222 ATLLVFPMPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMKELADASNTTAAG 286

  Fly   285 ESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLIT 349
            ||..:.:|.||||||::::.:.|.|||..|:.|:||:||||:|:||:.|||.:.||::|:||:||
  Fly   287 ESLSQMIHRPEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIIT 351

  Fly   350 TCPMGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQI-EILKEVPYLPVVAIVGFIVLSTLGLYT 413
            |..|..|.|.|||:.:||.|..||..||.||||.:.. :.|..:.:|||..||..||.||:|:.|
  Fly   352 TLFMSGIFEKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLHWLPVACIVAHIVFSTMGMLT 416

  Fly   414 LPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVY 478
            ||||||||:|||:.||.|||:.:..||.::|::||.||.::..||.:|.|..:..::..|..|:.
  Fly   417 LPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAAAFIG 481

  Fly   479 LALPETRRRTLLEIEEQFRSGRSKSQ----NQADVEMKEVFVRK 518
            :.:||||.|||.|:||::::|:...:    |..|||:.|||::|
  Fly   482 VFVPETRGRTLEELEERWQTGKFSRRLTIVNLKDVELHEVFLKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	196/432 (45%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	201/438 (46%)
CG4607	NP_572380.1	MFS	55..484	CDD:119392	193/428 (45%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	194/427 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	1	1.000	-	-		H71762
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D104662at6656
OrthoFinder	1	1.000	-	-		FOG0017008
OrthoInspector	1	1.000	-	-		mtm9732
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.860