DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001100921.1	Gene:	Slc2a12 / 308028	RGDID:	1310175	Length:	621	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	134/634 - (21%)
Similarity:	245/634 - (38%)	Gaps:	166/634 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LNQNGSE---------SNGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTL 63
            |||.|.|         |.|:......|         ||..|      .:..:.|.:.....|..|
  Rat    13 LNQKGREAETDGSCGASGGRHPACAGG---------PGMFT------FLTSVTAAISGLLVGYEL 62

  Fly    64 AMPTATLHQLKDTTEPVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILA 128
            .:.:..|.|::..   :.|...:.....|...:.|.:..|..|.|:||.||:.::|:.:.|:.|.
  Rat    63 GLISGALLQIRTL---LALTCHEQEMVVSSLLIGAFLASLTGGVLIDRYGRRLTIILSSCLLGLG 124

  Fly   129 WILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGI 193
            .::|..      :..:..||..|..:||.:.|:|....||.|||:....||.|:....:.:..||
  Rat   125 SLVLIL------SLSYTLLITGRVAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVTGI 183

  Fly   194 TILYGIGYCIRDDFRLIALICCGYQ----LVALLCVLP------LPESHCWLLSKKRVTEAKRSL 248
            ...|...|.       .|.|..|::    ||..|.||.      ||.|..:|:.|.:...|.:.|
  Rat   184 LFAYISNYA-------FANISNGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEEAAGKVL 241

  Fly   249 NYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHEPEVYKPLVIL-MSLFAFQQL 312
            ...|..:        ...||..|::.||:..   .:.|||......:..:..::: ::|..|.|.
  Rat   242 RKLRVIS--------DTAEELTLIKSSLKDE---YQYSFWDLFRSKDNMRTRILIGLTLVFFVQT 295

  Fly   313 TGIFVVIVFAVQISQEAGIEID--PFMCAVLIGLARLITTCPMGYILEWWGRR---------RAG 366
            ||...::.:|..:.:..|.:.:  ..:.:..:|:.::::|.|...:::..|.:         .|.
  Rat   296 TGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHVGSKTFLCIGSSVMAA 360

  Fly   367 IISTLGM----------SVC-------------MFLLAGHSQI------EILKEV-PY------- 394
            .:.|:|:          ::|             :|...|:..:      |.||.| ||
  Rat   361 SLLTMGIVNLNINMNFTNICRSHSPLNQSLEELVFYATGNLSVSNSSLGEHLKRVTPYSKGLFIP 425

  Fly   395 -----------------------------------------LPVVAIVGFIVLSTLGLYTLPFFM 418
                                                     |.:.:::.::...::||..:|:.:
  Rat   426 LGNGMEPKGEMAFTSLPNAGLSRTDRQGVTDPAVVPAVYKWLSLASLLVYVAAFSIGLGPMPWLV 490

  Fly   419 ISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPE 483
            :||:||..:||.|..||.::...|:.::..|:..:.:.:|:|....|:.||:|.:|.||.|.:||
  Rat   491 LSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLSWVCFIYTVMSLTSLAFVVLFIPE 555

  Fly   484 TRRRTLLEIEEQFRSGRSK-----------SQNQADVEMKEVFVRKPEE 521
            |:..:|    ||.....||           |.:|.::...::...||:|
  Rat   556 TKGCSL----EQISMELSKANYVKNNICFMSHHQEELVPTQLQKTKPQE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	109/529 (21%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	114/535 (21%)
Slc2a12	NP_001100921.1	MFS_GLUT12_Class3	46..564	CDD:340993	115/548 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750