DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and SLC2A8

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_055395.2	Gene:	SLC2A8 / 29988	HGNCID:	13812	Length:	477	Species:	Homo sapiens

Alignment Length:	490	Identity:	144/490 - (29%)
Similarity:	238/490 - (48%)	Gaps:	50/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPV-HLNDSQASWFASVNALS 97
            |||......||..:|...|.:|..|.|..|...:..:..|:....|. .|:|:.||||.:|..|.
Human    15 PPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLG 79

  Fly    98 APIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLAS 162
            |..||:|.|:|:||.|||.||::.:|..:..:.::....:      .|.|:..|.:.|:..|:||
Human    80 AAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQD------VWMLLGGRLLTGLACGVAS 138

  Fly   163 APPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLCVLP 227
            ....||.:||:.|..||.|.....:.|..||.:.|..|:.:  ::|.:|::.|....:.||.:..
Human   139 LVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVL--EWRWLAVLGCVPPSLMLLLMCF 201

  Fly   228 LPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLH 292
            :||:..:||::.|..||..:|.:..|..:..|  .|.:..|        |..:.|:       |.
Human   202 MPETPRFLLTQHRRQEAMAALRFLWGSEQGWE--DPPIGAE--------QSFHLAL-------LR 249

  Fly   293 EPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYIL 357
            :|.:|||.:|.:||.|||||:|:..|:.:|..|.:||..: |..:.:|::|:.:::.|.....|:
Human   250 QPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFK-DSSLASVVVGVIQVLFTAVAALIM 313

  Fly   358 EWWGRR----RAGII---STLGMSVCMFLLAG----HSQIEILKEVPYLPVVAIVG--------- 402
            :..|||    .:|::   ||........|..|    .|.:.|...|...||.|.||
Human   314 DRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSM 378

  Fly   403 --FIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFII 465
              ||....:|...:|:.::||:||..|:|.|:|:.|.....::|:|.|.:..:.|.|.....|.:
Human   379 CLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWL 443

  Fly   466 FGVMALFALIFVYLALPETRRRTLLEIEEQFRSGR 500
            .....:|:::|....:|||:.:||.:|...| .||
Human   444 ASAFCIFSVLFTLFCVPETKGKTLEQITAHF-EGR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	129/452 (29%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	132/458 (29%)
SLC2A8	NP_055395.2	Dileucine internalization motif. /evidence=ECO:0000250\|UniProtKB:Q9JJZ1	12..13
		xylE	36..472	CDD:182225	134/461 (29%)
		MFS	38..459	CDD:119392	127/446 (28%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	267..273		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.810