DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and itr1

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_593858.2	Gene:	itr1 / 2543145	PomBaseID:	SPAC4F8.15	Length:	575	Species:	Schizosaccharomyces pombe

Alignment Length:	553	Identity:	127/553 - (22%)
Similarity:	240/553 - (43%)	Gaps:	81/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SNGKQARIVSGLDRLLKTPPPGEQT---RAVRRQV-IAVILANVGVFSTGMTLAMPTATLHQLKD 75
            |||.::|..|.:.  |..|.....|   :.|.:.| :....|.:|....|....:.:..|..:..
pombe    55 SNGARSRSNSNIS--LSEPHALNDTVEDQPVSKWVWVLAFAAGIGGLLFGYDTGVISGALVVIGT 117

  Fly    76 TTEPVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQ 140
            :.....|.:....:..|..:|.|.:||:::|.|.|..|||..:.:.:::||:..|:..|...
pombe   118 SLGGHELTNGGKEFITSATSLGALLGGIIAGALADFFGRKPVIAIASIIIIVGSIVQVTAHH--- 179

  Fly   141 NAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYC--- 202
               .|.:||.||::|.|:|:||....:|.:||:..|.||.|::...:.:..|..|.|||...
pombe   180 ---LWHMIVGRFVIGWGVGIASLIIPLYLSEIAPSKIRGRLVIIYVLLITAGQVIAYGIDTAFEH 241

  Fly   203 IRDDFRL---IALICCGYQLVALLCVLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHP- 263
            :.:.:|.   :|::...:||..|:.   ||||...|:.|:|..||..:|      .:.....||
pombe   242 VHNGWRWMVGLAMVPAAFQLFILIW---LPESPRLLVKKERSQEAYNTL------ARIYPTAHPY 297

  Fly   264 QVLEEFQLLQKSLQ-----QRNTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAV 323
            ::..:..|:|:.::     .|...:.::|......|..::.|::...|.|.|||:|...::.|:.
pombe   298 EIKTKLYLIQEGVRDPFSGSRWQKIVKTFKELYFNPSNFRALILACGLQAMQQLSGFNSLMYFSS 362

  Fly   324 QISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFL--LAGHSQI 386
            .|.:..|.. :|....::|.....:.|.....:::::|||...:::..||...:.:  :|.|
pombe   363 TIFEVVGFN-NPTATGLIIAATNFVFTIVAFGVIDFFGRRILLLLTVWGMIAALIVCAVAFH--- 423

  Fly   387 EILKEVPYLP-------------------VVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPAS 432
                   :||                   :::::.::.....||..|| :..|||||..|||..:
pombe   424 -------FLPKDENGNYTSGQSNAWAIVVLISMIVYVASYASGLGNLP-WQQSELFPMSVRGLGT 480

  Fly   433 GLTVAV------GMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLE 491
            |::.||      |:..||:.|.:      .:..:..|.::|.:.....:......|:....|:.|
pombe   481 GMSTAVNWAGNLGIGASFLTLMS------EITPTGTFALYGGLCFLGWLGALFCYPDLTDYTIEE 539

  Fly   492 IEEQFRSG---RSKSQNQADVEMKEVFVRKPEE 521
            |.|..:.|   |...::...|..:..:.|:.:|
pombe   540 IGELLKHGFGVRESMRHLKRVRQERAWSREDKE 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	107/468 (23%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	110/474 (23%)
itr1	NP_593858.2	Sugar_tr	90..544	CDD:278511	112/486 (23%)
itr1	NP_593858.2	MFS	92..529	CDD:119392	107/469 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810