DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8249 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	135/527 - (25%)
Similarity:	237/527 - (44%)	Gaps:	74/527 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPV 80
            |..|..|:|....:|..|...      ||..|     |..:..|...|.:..|  |...|..|
  Rat    32 NAPQEVIISHYRHVLGVPLDD------RRATI-----NYDINGTDTPLIVTPA--HTTPDAWE-- 81

  Fly    81 HLNDSQAS-------WFASVNALSAPIGGLLS----GFLLDRIGRKKSLIVLNVLIILAWILLAT 134
              .:::.|       |..||::.:  :||:::    |:|.|::||.|:::..|.|.:...:|:..
  Rat    82 --EETEGSAHIVTMLWSLSVSSFA--VGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGC 142

  Fly   135 PSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRG--------SLILGTSISVAG 191
            ......:|.   :|..|.:.|:..||.|....:|..||:....||        :|:.|..||...
  Rat   143 SKFGPAHAL---IIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIA 204

  Fly   192 GITILYGIGYCIRDDFRLI-------ALICCGYQLVALLCVLPLPESHCWL-LSKKRVTEAKRSL 248
            |::.:.|    .:|.:.::       ||:.|   |:.|.|    |||..:| |..:....||:||
  Rat   205 GLSFILG----NQDYWHILLGLSAVPALLQC---LLLLFC----PESPRYLYLKLEEEVRAKKSL 258

  Fly   249 NYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLT 313
            ...||   ::::|     ::...::|..::.:|..|.|..:...:|...:|:|:.:.|...||.:
  Rat   259 KRLRG---TEDVT-----KDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFS 315

  Fly   314 GIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVC-M 377
            ||..:..::..|.|.|||. .|....:.:|...:|.|.....::|..|||...:...:||..| :
  Rat   316 GINGIFYYSTSIFQTAGIS-QPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAV 379

  Fly   378 FLLAGHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFI 442
            |:..|...::....:.|:.:.||..|:....:|...:|:||::|.|.|..|..|..|........
  Rat   380 FMSLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVC 444

  Fly   443 SFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFR--SGRSKSQN 505
            :|::...:..|.::||....|:..||:.:|.| |.:..:|||:.::..||..:||  || |....
  Rat   445 NFIIALCFQYIADFLGPYVFFLFAGVVLIFTL-FTFFKVPETKGKSFDEIAAEFRKKSG-SAPPR 507

  Fly   506 QADVEMK 512
            :|.|:|:
  Rat   508 KAAVQME 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	113/457 (25%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	116/463 (25%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	125/498 (25%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850