DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	490	Identity:	145/490 - (29%)
Similarity:	242/490 - (49%)	Gaps:	44/490 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PGEQTRA----VRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEP-VHLNDSQASWFASVN 94
            |||:.||    .||..:|...|.:|.||.|..|...:..:.:||.:::| :||:..|||||.||.
Mouse    23 PGERERAGALKNRRVFLATFAAVLGNFSFGYALVYTSPVIPELKLSSDPALHLDKIQASWFGSVF 87

  Fly    95 ALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMG 159
            .|.|..|||.:..|.|.:|||.|::...|...:.:.::|....      .|.|::.|.:.|...|
Mouse    88 TLGAAAGGLSAMLLNDLLGRKLSIMFSAVPSAIGYAIMAGARG------LWMLLLGRMLTGFAGG 146

  Fly   160 LASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLC 224
            |.:|...||.:||:.|..||:|.....:....|...||.:|..:  .:|.:|:...|..|:.:|.
Mouse   147 LTAACIPVYVSEIAPPDVRGALGATPQLMAVFGSLSLYALGLLL--PWRWLAVAGEGPVLIMILL 209

  Fly   225 VLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWR 289
            :..:|.|..:||||.|..||.::|.:.|    :|...|    .||:.:|.:::::::.|.   |.
Mouse   210 LSFMPNSPRFLLSKSRDEEALQALTWLR----ADSEVH----WEFEQIQDNVRRQSSRVS---WA 263

  Fly   290 NLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMG 354
            ...||.||:|::|.:.:...||||||..::|:...|.....:.:.....|.::|..||::.....
Mouse   264 EAREPRVYRPVLIAVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAA 328

  Fly   355 YILEWWGRRRAGIIS---------TLGMSVCMFL---LAGHSQIEIL-------KEVPYLPVVAI 400
            ..::..||:....:|         |||:.| .|:   |..:|.:||:       ..:..:|::|.
Mouse   329 VTMDLAGRKVLLYVSASVMFAANLTLGLYV-QFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLAT 392

  Fly   401 VGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFII 465
            :.||:...:|...:.:.::||:.|.:.||.||||.|.|....:||:...:.......|:...|..
Mouse   393 MLFIMGYAMGWGPITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFF 457

  Fly   466 FGVMALFALIFVYLALPETRRRTLLEIEEQFRSGR 500
            |..:.|.:|:|....:||||.|:|.:||..|.:.|
Mouse   458 FSAICLLSLLFTGCCVPETRGRSLEQIEAFFHTRR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	127/449 (28%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	131/455 (29%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	134/464 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850