DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and K08H10.6

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_505572.1	Gene:	K08H10.6 / 187181	WormBaseID:	WBGene00010698	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	121/514 - (23%)
Similarity:	213/514 - (41%)	Gaps:	92/514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAM--PTATLHQ--LKDTTE---PVHLN 83
            |:|.|:| ||...||.:...|:|..   .|.|..|..::.  |.:.:.|  :.|..:   ...|:
Worm     6 LERNLET-PPHLTTRLLATSVVATF---AGGFHFGYLISAVNPLSEILQQFIVDNLQNRYSYELS 66

  Fly    84 DSQAS--WFASVNAL--SAPIGGLLSGFLLDRIGRKKSLIVLNVLII-------LAWILLATPSE 137
            .||.|  |.:....|  .|.||..:|.|||..||.:.||::..:|.:       ||:.|....
Worm    67 SSQLSLIWSSLAGCLFIGAMIGAYISIFLLQSIGPRNSLLLAAILQLFSAPVFGLAYSLRLCE-- 129

  Fly   138 SDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYC 202
                    .|.:||.:.|:...:..:..||:..|||..|.||   |..|:|   |:     ||.|
Worm   130 --------LLPISRILSGIAFAIGISAQGVFLTEISPAKFRG---LTNSLS---GL-----IGNC 175

  Fly   203 IRDDFRLIALICCGYQL------------VALLCVLPL-------PESHCWLLSKKRVTEAKRSL 248
            .   |.|.|.:...|.|            ..:.|||.:       .:|..:|||..:::|.:.::
Worm   176 A---FLLAATLGTPYVLGTVTQWKYIFFIETIPCVLHILVNITTFHDSPTYLLSIGKISEGESAI 237

  Fly   249 NYFRGFNKSDEITH-PQVLEEFQLLQKSLQQRNTAVKESFWRN-LHEPEVYKPLVILMSLFAFQQ 311
            ..:.|     |..| .:::|:.:::       :..|||...|. |.:....:.|.:.:::.....
Worm   238 KVYYG-----ETCHIKKIMEDLRII-------DNGVKEKSLRQILKDKGCAQALSLAVAINFSVA 290

  Fly   312 LTGIFVVIVFAVQISQEAGIEIDPFMCAV---LIGLARLITTCPMGYILEWWGRRRAGIISTLGM 373
            .:||..:..|...:.|..|  ..|...||   |...|.:::.......::..|||...|.|.|.:
Worm   291 FSGIVAISFFGTFLLQTIG--FSPEGSAVANSLCSFASIVSALLAAIAMDKIGRRPLLITSLLVL 353

  Fly   374 S-VCMFLLAGHSQIEILKEV----PYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASG 433
            : :.:|:::.....:..|:.    |:|.:..:..|:.  ::|:.....|:.:||.|.........
Worm   354 ALINIFMMSLVFLYDSTKDSFLAWPFLALFVLFTFVF--SIGIGPAAVFIGAELAPPGTISKMQS 416

  Fly   434 LTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEI 492
            .:.:|....||:....|..:.|.:| ...|::|.|.......:.|:.||||:.::.:||
Worm   417 YSTSVQFAGSFICPIIYLQLVESIG-GFAFMLFIVPLTITAAYFYMYLPETKGKSPVEI 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	104/476 (22%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	109/480 (23%)
K08H10.6	NP_505572.1	MFS_GLUT_Class1_2_like	24..469	CDD:340915	111/488 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920