DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and F48E3.2

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_509266.1	Gene:	F48E3.2 / 185981	WormBaseID:	WBGene00018603	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	115/512 - (22%)
Similarity:	217/512 - (42%)	Gaps:	84/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VIAVILANVGVFSTGMTLAMPTATLHQLK-----DTTEPVHLNDSQASW----FASVNALSAPIG 101
            :::.:||...:|..|.|.|.|...:...:     ...||..|::|:..|    ..::..:....|
Worm    10 ILSAVLAITAIFQMGYTNAYPNTAIGSFRIFLNESANEPYTLSNSEFEWAWSAMLAIYFIGFAAG 74

  Fly   102 GLLSGFLLDRIGRKKSLI------VLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGM-G 159
            .::|..:.||||||.:|.      :|:.||.|..|:|..|.     .|.:..:|......:.| |
Worm    75 SVISAGVADRIGRKWTLFLGTCGSLLSSLIALFAIILKMPL-----MFGFSRLVMSLSAAISMNG 134

  Fly   160 LASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLC 224
            |.     :...|.|....||  ::..:..:|..||.|.| |.     |.:.:::  |..:|.|:.
Worm   135 LI-----LLFQESSPSHMRG--LISFNAEMAFVITNLIG-GL-----FGMQSIL--GQNIVGLIA 184

  Fly   225 VLPLPES-HCWL------------LSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSL 276
            |..:|.| .|:|            |.|...|||.|:|.:::  |..||.....||.:.:|.::.:
Worm   185 VSIIPSSVACFLTVFLKESPKYLFLKKHDATEAGRALQFYQ--NIKDEEEKMNVLNDLKLEKEEM 247

  Fly   277 QQR----------NTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGI 331
            ..:          |..|:..|               |:.|...|....::.|:.::.....:||.
Worm   248 GHQKNGSLFDIMANQPVRRGF---------------LLGLATMQLTASVWPVVFYSTDFLMDAGF 297

  Fly   332 --EIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQI--EILKEV 392
              |:...:...::.|:.|.|...| :|:|.:.|:.. :|.|..:::...|:...|.|  .....:
Worm   298 SYELSESVSTGMLFLSSLSTIVGM-FIVEKYSRKWL-LIGTASVNIAAILVFSLSAILSHYWTWI 360

  Fly   393 PYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVV-LKTYPGIKEY 456
            .|..::.::...:..::.:..:.:|:.|||.|...|..:..|.:|:...::.|: ..|:| :.:.
Worm   361 GYGCIICLILHGISYSVAMGPIAWFITSELVPINFRAASQSLVLALNHTVALVLAFLTFP-LYKT 424

  Fly   457 LGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFRSGRSKSQNQADVEMKE 513
            :|.....|.|.:..:..:|.:.|.||||:.:.:..|.||.|..::|.:....:|.:|
Worm   425 IGPITLVIFFVIPGILCIIMLILYLPETKDKHINVIVEQLRETKAKRKESQKLETEE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	103/473 (22%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	107/479 (22%)
F48E3.2	NP_509266.1	MFS_GLUT_Class1_2_like	12..455	CDD:340915	108/482 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930