DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8249 and ZK829.9

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_502272.1	Gene:	ZK829.9 / 178134	WormBaseID:	WBGene00014097	Length:	492	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	111/546 - (20%)
Similarity:	200/546 - (36%)	Gaps:	149/546 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPVHLNDS--------------------Q 86
            :|..:|..:|..:..|.:|.:.......:|:|.:     :||:|                    .
Worm    13 IRLLLICSLLTAMTNFPSGFSHTSVNTAVHKLNE-----YLNNSFTERYRPLDHEEVSLLKSGIN 72

  Fly    87 ASW--FASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIV 149
            ::|  |..|.|:|:|       ||.|..|||.:..:....:.||..:....|.:..:..   ||.
Worm    73 SAWYLFQVVGAMSSP-------FLCDNYGRKVAFALSIAFMTLAGAMQMLASFTPYSEV---LIA 127

  Fly   150 SRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGY---CIRDDFRLIA 211
            .|.:..|...|:.|...:|..|||....||::            :.||..||   |      |:.
Worm   128 GRLIAAVFSPLSDAALILYLQEISPSSLRGTM------------SSLYSTGYSTMC------LLG 174

  Fly   212 LI-----CCGYQLVALLCV------------LPLPESHCW-LLSKKRVTEAKRSLNYFRGFNKSD 258
            ::     ..|:.|..||.|            |.:|::..: ||.||....|.:||.:|:|.....
Worm   175 MLLGHEGLLGHSLSVLLFVPVIPGILSTAFILWMPDTPKFLLLVKKDKVAALKSLRFFQGSLPDQ 239

  Fly   259 EITHPQVLEEFQLLQKSLQQRNTAVKE------SFWRNLHEPEVYKPLVILM------------- 304
            .:    :::..:...|.....|...:|      |....|.:|.:.|.:::.:
Worm   240 TL----LIDSMEHHHKEDANNNNNSEEKADSATSVMHILKKPHLRKAMMLSVSAAILTLPFYPIL 300

  Fly   305 --SLFAF---------QQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILE 358
              |.|.|         .||...|:::|..:.           .:|:.||     |...|
Worm   301 QNSTFFFTDMGVDMKTSQLASSFMMVVLTIS-----------SICSTLI-----IDKLP------ 343

  Fly   359 WWGRRRAGIISTLGMSVCMFLLAGHSQIEILKEVPYLPVVAI---VGFIVLSTLGLYTLPFFMIS 420
                 |..::.|.|....:||     .|..:.|..:...:|:   .|||:...:|:..:.:.:..
Worm   344 -----RRILLLTCGSCTVLFL-----TIFAVSEQMHQKSIAMGACFGFIMSYGIGVGPVIWSIPP 398

  Fly   421 ELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEY--LGMSNCFIIFGVMALFALIFVYLALPE 483
            ||.|...|.....|..::...:  ||:..:..|..:  :|..:..::|.:.:.|||:::.:.|||
Worm   399 ELSPLADRSMMFCLVYSIHSCL--VVVTNFATIPLFMSIGAFSFVLLFAIPSAFALVYLLVCLPE 461

  Fly   484 TRRRTLLEIEEQFRSGRSKSQNQADV 509
            |..|.:..|..:.:......:...||
Worm   462 TSGREIHVIINELKGIVEDKEPSRDV 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	101/507 (20%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	105/513 (20%)
ZK829.9	NP_502272.1	MFS	19..465	CDD:391944	105/516 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870