DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	502	Identity:	140/502 - (27%)
Similarity:	241/502 - (48%)	Gaps:	50/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KTPP-PGEQTRA----VRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEP-VHLNDSQASW 89
            |.|| ||::.|.    .:|..:|...|.:|.||.|..|...:..:..|:.:.:| :||..|||||
Human    19 KPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASW 83

  Fly    90 FASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFML 154
            |.||..|.|..|||.:..|.|.:|||.|::...|.....:.|:|....      .|.|::.|.:.
Human    84 FGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHG------LWMLLLGRTLT 142

  Fly   155 GVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQL 219
            |...||.:|...||.:||:.|..||:|.....:....|...||.:|..:  .:|.:|:......|
Human   143 GFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLL--PWRWLAVAGEAPVL 205

  Fly   220 VALLCVLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVK 284
            :.:|.:..:|.|..:|||:.|..||.|:|.:.||       |...|..||:.:|.:::::::.|.
Human   206 IMILLLSFMPNSPRFLLSRGRDEEALRALAWLRG-------TDVDVHWEFEQIQDNVRRQSSRVS 263

  Fly   285 ESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLIT 349
               |.....|.|.:|:.:.:.:...||||||..::|:...|.....:.:.|...|.::|..||::
Human   264 ---WAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLS 325

  Fly   350 TCPMGYILEWWGRR-----RAGIISTLGMSVCMFL------LAGHSQIEILKE------------ 391
            .......::..||:     .|.|:....:::.:::      |:.:|...:..|
Human   326 VLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAP 390

  Fly   392 ---VPYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGI 453
               :..:|::|.:.||:...:|...:.:.::||:.|.:.||.||||.|......:||:.|::..:
Human   391 AGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPV 455

  Fly   454 KEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFRSGR 500
            ....|:...|..|..:.|.:|:|....:|||:.|:|.:||..||:||
Human   456 VSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	121/456 (27%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	124/462 (27%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/8 (63%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	127/471 (27%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850