DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8249 and slc2a5

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001352581.1	Gene:	slc2a5 / 100006415	ZFINID:	ZDB-GENE-060222-2	Length:	511	Species:	Danio rerio

Alignment Length:	538	Identity:	131/538 - (24%)
Similarity:	244/538 - (45%)	Gaps:	68/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEQHQNLNQNGSESNGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVG-VFSTGMTLA 64
            |||:   :|....|..||...|::.                      |.::|..| .|..|..:|
Zfish     1 MDEE---VNMKKGERKGKVTLILAA----------------------ASLVAGFGSSFQYGYNVA 40

  Fly    65 MPTATLHQLKDTTEPVH------LNDSQASWFASVNALSAPIGG----LLSGFLLDRIGRKKSLI 119
            :..:...:::.....::      ::|:..:...||.....|:||    |:...|:::.|||.:|:
Zfish    41 VVNSPAPEMQQFYRRIYVDRYGPMSDNLLTLLWSVTVSMYPLGGFFGSLMVAPLVNKFGRKGTLL 105

  Fly   120 VLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILG 184
            ..|:..|:..|::..   |:....|..:||:||::|:..||:|....:|..||:....||::.:.
Zfish   106 FNNIFSIVPAIMMGV---SEVAGSFEIIIVARFLVGICAGLSSNVVPMYLGEIAPKNYRGAVGIV 167

  Fly   185 TSISVAGGITI--LYGIGYCI-RDDFRLIALICCGYQLVALLCVLP-LPESHCWLLSKKRVTE-A 244
            ..:.:..||.:  ::||...: ..:...|.|...|......|.:|| .|||..::|.:|...: |
Zfish   168 PQLFITVGILVAQIFGIRSILGNKEGWPIMLGLTGIPAAIELLLLPFFPESPRYMLIQKGDEKTA 232

  Fly   245 KRSLNYFRGFNKSD-EITHPQVLEEFQLLQKSLQQRNTAVKESF-WRNLHEPEVYKPLVILMSLF 307
            ::.|...||....| |:...:|.|:.:..:..|...|.....|. |:.|.        ||.|::
Zfish   233 RKGLQRLRGCEDVDEELCEMRVEEQSERAEGRLSLLNLFTFRSLRWQLLS--------VIFMNM- 288

  Fly   308 AFQQLTGIFVVIVFAVQISQEAGIEIDPFM-CAVLIGLARLITTCPMGYILEWWGRRRAGIISTL 371
             .|||:|:..:..:|..|...||:..|... ..|..|...:..|....:|:|..||:   ::..:
Zfish   289 -GQQLSGVNAIYYYADSIYSSAGVSEDHVQYVTVGTGAVNVFMTITAVFIVEKSGRK---LLLLI 349

  Fly   372 GMSVC-----MFLLAGHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPA 431
            |..:|     :..:|.:.| ..|..:||:.:|.::.:::...:|...:|..:.:|:|.|..|.||
Zfish   350 GFGICCAACVILTIALYFQ-TTLDWIPYVSIVCVIVYVIGHAIGPSPIPTVITTEMFRQSSRPPA 413

  Fly   432 SGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQF 496
            ..:..:|....:|.|...:|.::..||..: ||||..:.|..||::::.:|||:.:|.||..:.|
Zfish   414 FMVAGSVHWLSNFTVGLVFPFLERGLGPYS-FIIFACICLATLIYIWIVIPETKNKTFLETSKLF 477

  Fly   497 RSGRSKSQNQADVEMKEV 514
             :.|:|.:..|:....|:
Zfish   478 -AQRNKVEIMAEASDSEI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	111/453 (25%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	114/458 (25%)
slc2a5	NP_001352581.1	Sugar_tr	23..477	CDD:306568	118/471 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910