DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poxn and PAX9

DIOPT Version :9

Sequence 1:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001359005.1	Gene:	PAX9 / 5083	HGNCID:	8623	Length:	341	Species:	Homo sapiens

Alignment Length:	388	Identity:	143/388 - (36%)
Similarity:	180/388 - (46%)	Gaps:	88/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PHTGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGS 66
            |..|:  |||||||||||||||:.:|.|||:||..|:|||||||||.||||||||||.|:.||||
Human     3 PAFGE--VNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGS 65

  Fly    67 IRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRN 131
            |.||:|||||.: |.||||||.|...|:.:.|:||||||::|....|||..:|||:|||:|||||
Human    66 ILPGAIGGSKPR-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRN 129

  Fly   132 S-GLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGG-QAPPPPVTVAP---PTPAATPSIA 191
            . |           |.|......:...||....|:..|.. .:.|.|:|.|.   |||...|:|
Human   130 KIG-----------NLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAI- 182

  Fly   192 RYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHS-------HGLNPNVSGLDLSYSALHKHWLWNP 249
                |.::.|           |:..||   .||       ..:...||.....:|...:.|
Human   183 ----PGSVAM-----------PRTWPS---SHSVTDILGIRSITDQVSDSSPYHSPKVEEW---- 225

  Fly   250 SLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSESSIDLSTPG----- 309
            |.|........|..|.:|.:    .|.....|....|.:...|:|.|..:.|.....||.
Human   226 SSLGRNNFPAAAPHAVNGLE----KGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPY 286

  Fly   310 ------------------AAGDALS--DCDSGKSSPAALSLTASGGGNGAGSAPEASPGSTLS 352
                              |.|.:||  :||    .||:|:.      .|..:|.|.|...|.|
Human   287 MTYSAAPSGYVAGHGWQHAGGTSLSPHNCD----IPASLAF------KGMQAAREGSHSVTAS 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	86/128 (67%)
PAX9	NP_001359005.1	PAX	6..131	CDD:238076	86/127 (68%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	7..63		42/57 (74%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	82..130		27/47 (57%)
		Interaction with KDM5B. /evidence=ECO:0000269\|PubMed:12657635	168..189		8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970