DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poxn and PAX5

DIOPT Version :9

Sequence 1:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	405	Identity:	150/405 - (37%)
Similarity:	181/405 - (44%)	Gaps:	119/405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGSIR 68
            ||..|||||||||||||||||.||:|||:||..|||||||||||.||||||||||.|:||||||:
Human    15 TGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIK 79

  Fly    69 PGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRNSG 133
            ||.|||||.| ||||.||:||...|.:|..|||||||::|..:||||..:|||:||||||:|
Human    80 PGVIGGSKPK-VATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIR--- 140

  Fly   134 LWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIARYAKPPA 198
                  |..|                           |.|..||..:..:..:|.|:.:.:   :
Human   141 ------TKVQ---------------------------QPPNQPVPASSHSIVSTGSVTQVS---S 169

  Fly   199 LMMNSAGE-----------MPIKPAPKMPPSMG-------HGHS----HGLNPNVSG-------- 233
            :..:|||.           .|.....|.....|       :|||    ..|...:.|
Human   170 VSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQL 234

  Fly   234 --LDLSYSALHKHWLWNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGF 296
              ||..:...|.      |.::.|...|:.:...........|||.  ..|.|..||.|.|
Human   235 EVLDRVFERQHY------SDIFTTTEPIKPEQTTEYSAMASLAGGL--DDMKANLASPTPA---- 287

  Fly   297 TKSESSIDLSTPGAAGDALSDCDSGKSSPAA-----LSLTASG-------GGNGAGSAPEAS--- 346
                 .|..|.||.           :|.|..     .|.|..|       .|.|:.|||..:
Human   288 -----DIGSSVPGP-----------QSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMV 336

  Fly   347 PGSTLSHSRKRNPYS 361
            |||..|.|    |||
Human   337 PGSEFSGS----PYS 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	93/127 (73%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/5 (60%)
		PAX	16..140	CDD:128645	92/124 (74%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		47/55 (85%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		28/56 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		6/35 (17%)
		Pax2_C	279..389	CDD:403565	27/93 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002430
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810