DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Poxn and PAX2

DIOPT Version :9

Sequence 1:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_003981.3	Gene:	PAX2 / 5076	HGNCID:	8616	Length:	432	Species:	Homo sapiens

Alignment Length:	420	Identity:	152/420 - (36%)
Similarity:	188/420 - (44%)	Gaps:	121/420 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HTGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRFYETGSI 67
            |.|..|||||||||||||||||.||:|||:||..|||||||||||.||||||||||.|:||||||
Human    14 HPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSI 78

  Fly    68 RPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRILRNS 132
            :||.|||||.| ||||.||.||...|.:|..|||||||::|..:.:||..:|||:||||||:|
Human    79 KPGVIGGSKPK-VATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIR-- 140

  Fly   133 GLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIARYAKPP 197
                   |..||           ..|....|...|    ...|..|:.|.|  |:|.::..:..|
Human   141 -------TKVQQ-----------PFHPTPDGAGTG----VTAPGHTIVPST--ASPPVSSASNDP 181

  Fly   198 ALMMNSAGEMPIKPAPKMPPSMGH-------------GH----------------SHGLNPN--- 230
                  .|...|.....:|.|.|.             .|                |.|..||
Human   182 ------VGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDS 240

  Fly   231 VSGLDLSYSALHKHW----------------LWNPSL--LYYTQAHIQAQAAASGGQF-LPYAGG 276
            .||:|    :|.||.                ...||.  ::....||:::   .|.:: ||....
Human   241 QSGVD----SLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSE---QGNEYSLPALTP 298

  Fly   277 YLPHAMAAAAASSTSALGGFTKSESSIDLSTPGAAGDALSDCDSGKSSPAALSLTASG-----GG 336
            .|....::.:||:...||    |..|...:.|...|..::            |.|..|     ..
Human   299 GLDEVKSSLSASTNPELG----SNVSGTQTYPVVTGRDMA------------STTLPGYPPHVPP 347

  Fly   337 NGAGSAPEAS-----PGSTLSHSRKRNPYS 361
            .|.||.|.::     |||..|    .||||
Human   348 TGQGSYPTSTLAGMVPGSEFS----GNPYS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	91/127 (72%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	90/124 (73%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		47/55 (85%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		26/56 (46%)
		homeodomain	255..>278	CDD:412151	2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..325		6/24 (25%)
		Pax2_C	305..>390	CDD:403565	23/89 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002430
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810