DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Poxn and PAX1

DIOPT Version :9

Sequence 1:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_006183.2	Gene:	PAX1 / 5075	HGNCID:	8615	Length:	534	Species:	Homo sapiens

Alignment Length:	478	Identity:	154/478 - (32%)
Similarity:	199/478 - (41%)	Gaps:	139/478 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HTGQAG----------------VNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSH 51
            |.|..|                |||||||||||||||:.:|.|||:||..|:|||||||||.|||
Human    80 HPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSH 144

  Fly    52 GCVSKILTRFYETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDP 116
            |||||||.|:.|||||.||:|||||.: |.||.|||.|...|:.:.|:||||||::|....|||.
Human   145 GCVSKILARYNETGSILPGAIGGSKPR-VTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDK 208

  Fly   117 SSVPSISSINRILRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAP 181
            .:|||:|||:|||||.                                   .|..|.|.|...:.
Human   209 YNVPSVSSISRILRNK-----------------------------------IGSLAQPGPYEASK 238

  Fly   182 PTPAATPSIARYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGLNPNVSGLDLSYSALHKHWL 246
            ..|:          .|.|..|...:.|. |:|..|.    |...|.:|.|.| ...:.::.:.|
Human   239 QPPS----------QPTLPYNHIYQYPY-PSPVSPT----GAKMGSHPGVPG-TAGHVSIPRSW- 286

  Fly   247 WNPSLLYYTQAH--------------IQAQAAASGGQFLP----YAGGYLPHAMAAAAASSTSAL 293
              ||      ||              ..|.|.:.|..:.|    :||      :...|..:|.|:
Human   287 --PS------AHSVSNILGIRTFMEQTGALAGSEGTAYSPKMEDWAG------VNRTAFPATPAV 337

  Fly   294 GGFTKSESSIDL------STPGAAGDALSDCDSGKSSPAALSLTASGGG--------NGAGSAPE 344
            .|..|.....|:      ||..|.|..|..|....|:...: .:|.|||        ..|...|.
Human   338 NGLEKPALEADIKYTQSASTLSAVGGFLPACAYPASNQHGV-YSAPGGGYLAPGPPWPPAQGPPL 401

  Fly   345 ASPGSTLS-HSRK-------RNPYSIEELLKKPEKRLRLDSNRLECLESSSCESSQDSPVAPPLE 401
            |.||:.:: |..:       ::| |.|..|..|..|.|..|           .:..|.|..|  .
Human   402 APPGAGVAVHGGELAAAMTFKHP-SREGSLPAPAARPRTPS-----------VAYTDCPSRP--R 452

  Fly   402 TPEDEDP-AEAEEEQEEEDSVEV 423
            .|....| ..|..|::.:...:|
Human   453 PPRGSSPRTRARRERQADPGAQV 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	86/143 (60%)
PAX1	NP_006183.2	PAX	98..225	CDD:238076	84/162 (52%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	101..157		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	176..224		26/47 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..480		16/66 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970