Protein Alignment Poxn and Pax8

DIOPT Version :9

• Sequence 1: NP_001261016.1
• Gene: Poxn / 36741
• FlyBaseID: FBgn0003130
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 521
• Identity: 161/521 - (30%)
• Similarity: 205/521 - (39%)
• Gaps: 195/521 - (37%)

  Fly     1 MPH----TGQAGVNQLGGVFVNGRPLPDCVRRRIVDLALCGVRPCDISRQLLVSHGCVSKILTRF 61
            |||    :|..|:|||||.||||||||:.||:||||||..|||||||||||.||||||||||.|:
Mouse     1 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRY 65

  Fly    62 YETGSIRPGSIGGSKTKQVATPTVVKKIIRLKEENSGMFAWEIREQLQQQRVCDPSSVPSISSIN 126
            |||||||||.|||||.| ||||.||:||...|.:|..|||||||::|..:.|||..:|||:||||
Mouse    66 YETGSIRPGVIGGSKPK-VATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSIN 129

  Fly   127 RILRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGPSNGYGGQAPPPPVTVAPPTPAATPSIA 191
            ||:|         |..||                               |..:...:..||.|::
Mouse   130 RIIR---------TKVQQ-------------------------------PFNLPMDSCVATKSLS 154

  Fly   192 RYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGL----------NPNVSGLD----------- 235
                |...::.|:...|    |:.|.|...|.::.:          |.|...:|
Mouse   155 ----PGHTLIPSSAVTP----PESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSDQDSCRLSI 211

  Fly   236 ---LSYSALHKHWLWNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMA-------------- 283
               .|.|...||...:.    ::|.|::|...       |:...:.|.|.|
Mouse   212 DSQSSSSGPRKHLRTDT----FSQHHLEALEC-------PFERQHYPEAYASPSHTKGEQGLYPL 265

  Fly   284 -----------AAAASSTSALGGFTKSESS----IDLSTPGAAGDALSDCDSGKSSPAALSLTA- 332
                       |...||.:.||....:..:    .|..:|.|......:..|..|:|::||.:|
Mouse   266 PLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSSTPSSLSSSAF 330

  Fly   333 -------SGGGNGAGSAP-EASP------------------------------------------ 347
                   |||..||...| .|.|
Mouse   331 LDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYAS 395

  Fly   348 -------------GSTLSHSRKRNPY-SIEELLKKPEKRLRLDSNRLECLESSSCESSQDSPVAP 398
                         |:..||:    || |..|..:.|...|         |.|....||...|.||
Mouse   396 SAIAGMVAGSEYSGNAYSHT----PYSSYSEAWRFPNSSL---------LSSPYYYSSTSRPSAP 447

  Fly   399 P 399
            |
Mouse   448 P 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	91/127 (72%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	90/124 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		45/55 (82%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		27/56 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		12/68 (18%)
		Pax2_C	344..455	CDD:372091	21/118 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810