DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Poxn and DUX4

DIOPT Version :9

Sequence 1:	NP_001261016.1	Gene:	Poxn / 36741	FlyBaseID:	FBgn0003130	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001280727.1	Gene:	DUX4 / 100288687	HGNCID:	50800	Length:	424	Species:	Homo sapiens

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	128/409 - (31%)	Gaps:	135/409 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PGSIG---GSKTKQVATPTVVKKIIRL--KEENSGMFAWEIREQLQQQRVCDPSSVPSISSINRI 128
            ||..|   |.:.:...|.:....::|.  |:...|:.|   ||:|.::... |.|...|...||.
Human    86 PGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAA---REELARETGL-PESRIQIWFQNRR 146

  Fly   129 LRNSGLWTDEMTSSQQNAAAAAAAAAAAAHQAGSGP---------SNGYGGQAPPPPVTVAP--- 181
            .|:.|         |...|.|.|....:|...|..|         :..:|...|.|.|..||
Human   147 ARHPG---------QGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGAL 202

  Fly   182 PTPAATPSIARYAKPPALMMNSAGEMPIKPAPKMPPSMGHGHSHGLNPNVSGLDLSYSALHKHWL 246
            |..|.....||.|  |||..:.|.  |.:...:..|:.|              |.:|:
Human   203 PQGAFVSQAARAA--PALQPSQAA--PAEGISQPAPARG--------------DFAYA------- 242

  Fly   247 WNPSLLYYTQAHIQAQAAASGGQFLPYAGGYLPHAMAAAAASSTSALGGFTKSESSIDLSTPGAA 311
                          |.|...|....|.|..:.||.               .||....|....|..
Human   243 --------------APAPPDGALSHPQAPRWPPHP---------------GKSREDRDPQRDGLP 278

  Fly   312 GD-ALSDCDSGKSSPAALSLTAS---------GGGNG-----------AGSAPEASPGSTLSHSR 355
            |. |::.....::.|....:.|.         |.|.|           ||:||...|....:.:.
Human   279 GPCAVAQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASAS 343

  Fly   356 KRN-----------------PYS-------IEELLKKPEKRLRLDSNRLECLESSSCESSQDSPV 396
            .|.                 |:|       ::|||..|| .|:.....||.......|:|::
Human   344 ARQGQMQGIPAPSQALQEPAPWSALPCGLLLDELLASPE-FLQQAQPLLETEAPGELEASEE--- 404

  Fly   397 APPLETP--EDEDPAEAEE 413
            |..||.|  |:|..|..||
Human   405 AASLEAPLSEEEYRALLEE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Poxn	NP_001261016.1	HTH	5..133	CDD:304362	18/68 (26%)
DUX4	NP_001280727.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Homeobox	27..74	CDD:306543
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..102		4/15 (27%)
		Homeobox	97..149	CDD:306543	13/55 (24%)
		DNA_pol3_gamma3	<141..319	CDD:331207	49/240 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..362		31/195 (16%)
		Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269\|PubMed:26951377	327..424		27/101 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		8/28 (29%)
		Important for transcriptional activation of target genes. /evidence=ECO:0000269\|PubMed:29618456	405..424		9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900