DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and LPXN

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001137467.1	Gene:	LPXN / 9404	HGNCID:	14061	Length:	391	Species:	Homo sapiens

Alignment Length:	355	Identity:	96/355 - (27%)
Similarity:	142/355 - (40%)	Gaps:	48/355 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1850 SSSKATTSSLSSSSASASASAS---------VARSSQSLTQASAITTTTNNQATTAYRSSNGSIT 1905
            |||.|....|..|:...|...|         .:|...:|.:.|.|.:..:|             |
Human     7 SSSDALLEELERSTLQDSDEYSNPAPLPLDQHSRKETNLDETSEILSIQDN-------------T 58

  Fly  1906 KP---NLASRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVF 1967
            .|   .|....:|..:.....|..|...|..:.|.|.|... .::.......|..|....|....
Human    59 SPLPAQLVYTTNIQELNVYSEAQEPKESPPPSKTSAAAQLD-ELMAHLTEMQAKVAVRADAGKKH 122

  Fly  1968 PPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFI 2032
            .||..|  ..:::|:..|...:.....|..:.|| |.               |.||...|.|..|
Human   123 LPDKQD--HKASLDSMLGGLEQELQDLGIATVPK-GH---------------CASCQKPIAGKVI 169

  Fly  2033 TALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIG 2097
            .|||:.|.|:||:|.  :|:..:....|.|..|..||...:.:..:|.|:.||..|....|.|:.
Human   170 HALGQSWHPEHFVCT--HCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMN 232

  Fly  2098 KHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYH 2162
            :.:|||.|.|..||::||...|..:|...||..|:..:|:.||..|..||.  :.::.|::..:|
Human   233 QTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVL--ENYLSAMDTVWH 295

  Fly  2163 SQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192
            .:||.|..|..:....||:...|||||:.|
Human   296 PECFVCGDCFTSFSTGSFFELDGRPFCELH 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	20/52 (38%)
		LIM	2081..2132	CDD:259829	19/50 (38%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	18/53 (34%)
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790	21/70 (30%)
		LIM2_Leupaxin	216..267	CDD:188792	19/50 (38%)
		LIM3_Leupaxin	275..327	CDD:188794	18/53 (34%)
		LIM4_Paxillin_like	334..385	CDD:188725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840