DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zasp52 and PDLIM7

DIOPT Version :9

Sequence 1:NP_001027420.2 Gene:Zasp52 / 36740 FlyBaseID:FBgn0265991 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_005442.2 Gene:PDLIM7 / 9260 HGNCID:22958 Length:457 Species:Homo sapiens


Alignment Length:442 Identity:130/442 - (29%)
Similarity:185/442 - (41%) Gaps:124/442 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1857 SSLSSSSASASASASV--------ARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRP 1913
            |.|:....:|.|..:|        ..::.|||...|    .|.......|.|.|......:.|:|
Human    31 SRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEA----QNKIRACGERLSLGLSRAQPVQSKP 91

  Fly  1914 SIASITAPGSASAPAP-------VPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDL 1971
            .        .|||||.       .||.:..|...||.||  |.:..|...| ..|..|.|  ||.
Human    92 Q--------KASAPAADPPRYTFAPSVSLNKTARPFGAP--PPADSAPQQN-GQPLRPLV--PDA 143

  Fly  1972 SDLNLNSNVDN---SPGAG---------------------------------------------- 1987
            |...|..|.::   .||.|                                              
Human   144 SKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQE 208

  Fly  1988 ---GKSA------------GAFG------------------ATSAPKRGRGILNKAAGPGV---- 2015
               |.:|            .||.                  ||..|.:.|..:.:||..||    
Human   209 PWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGG 273

  Fly  2016 ----RIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKY 2076
                :.|:|:.|:..|||.::.|||..:.|:.|:|  ..|.:.|::.||.||||.::|..|::..
Human   274 SNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVC--SQCGKVLEEGGFFEEKGAIFCPPCYDVR 336

  Fly  2077 LAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCF 2141
            .||:|:||..||.|:.::|:...:|..||||..|.....||.|::|:|..|||.|:.::|.|||.
Human   337 YAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCH 401

  Fly  2142 ACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNHA 2193
            .|.|.::||||::|||..::|..||.|..|:.||||::||:|..||.||:||
Human   402 GCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zasp52NP_001027420.2 PDZ_signaling 6..87 CDD:238492
DUF4749 150..>217 CDD:292558
LIM_ALP_like 282..333 CDD:188746
LIM1_Enigma_like_1 2020..2073 CDD:188839 20/52 (38%)
LIM 2081..2132 CDD:259829 21/50 (42%)
LIM3_Enigma_like_1 2140..2193 CDD:188845 26/52 (50%)
PDLIM7NP_005442.2 PDZ_signaling 5..79 CDD:238492 11/51 (22%)
Atrophin-1 <81..254 CDD:331285 34/185 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..142 20/72 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..226 2/49 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..258 3/18 (17%)
LIM1_Enigma 282..333 CDD:188836 20/52 (38%)
LIM2_Enigma 341..392 CDD:188840 21/50 (42%)
LIM3_Enigma 400..454 CDD:188842 28/54 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149569
Domainoid 1 1.000 78 1.000 Domainoid score I8783
eggNOG 1 0.900 - - E1_KOG1703
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1013114at2759
OrthoFinder 1 1.000 - - FOG0000055
OrthoInspector 1 1.000 - - otm41228
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24214
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.840

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