DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and PDLIM4

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_003678.2	Gene:	PDLIM4 / 8572	HGNCID:	16501	Length:	330	Species:	Homo sapiens

Alignment Length:	357	Identity:	107/357 - (29%)
Similarity:	153/357 - (42%)	Gaps:	56/357 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||:.||.:.:|:|||.:..|.|.|||.:..||......:.|.:||:.:....::.
Human    12 PWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHL 76

  Fly    83 VITVQR-GGSTWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDG 146
            .::|.| .|.:|            |::|    ....:.||:......|..|....:|..|..|.|
Human    77 TLSVSRPEGRSW------------PSAP----DDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTG 125

  Fly   147 ---GVKSIVNKQYNTP--VGIYSDESIAETLSAQAEVL-------AGGVLGVNFKKNEKEYQGDR 199
               |..|: ...|..|  ..:..:.|...||.||...|       |....|:...::.:...|
Human   126 PEDGRPSL-GSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLG-- 187

  Fly   200 SEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPV 264
            |||.:.|||       ||      |..|.:..|....:|.|......:..........|::....
Human   188 SEVYRMLRE-------PA------EPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTA 239

  Fly   265 NSPKPPSTG--GLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKL 327
            :....|.:|  |||.    ||.|...|.|..|:.:||..|.|||.|:.||.:||.:||:..:.:|
Human   240 SKLGAPLSGLQGLPE----CTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERL 300

  Fly   328 YCDIHAKQAAINNPPTGTEGYVPVPIKPNTKL 359
            ||:.|||  |...||   |||..|.:.||.|:
Human   301 YCESHAK--ARVKPP---EGYDVVAVYPNAKV 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	26/68 (38%)
		DUF4749	150..>217	CDD:292558	18/75 (24%)
		LIM_ALP_like	282..333	CDD:188746	22/50 (44%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
PDLIM4	NP_003678.2	PDZ_signaling	2..80	CDD:238492	26/67 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..180		18/76 (24%)
		DUF4749	148..220	CDD:406377	22/86 (26%)
		LIM_RIL	255..307	CDD:188835	23/51 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10447
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7397
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860