DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and PXL1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_013016.4	Gene:	PXL1 / 853965	SGDID:	S000001798	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	151/746 - (20%)
Similarity:	249/746 - (33%)	Gaps:	175/746 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1547 YNELNASPFPD-------RTRSPAPG---PPPNPLN--------AIRAPRMKEPETKSNILSVSG 1593
            ||.:..||||.       :|.....|   .|.||.:        :::|.....|.|:..  :||.
Yeast     2 YNSIYGSPFPKINPKVRYKTALERAGFDTKPRNPFSSQRNASTGSLQASVKSPPITRQR--NVSA 64

  Fly  1594 GPRL-------------QTGSITTGQS--YQGQLLAHSEQSSQSASQSYNQQPERITEQRVGNLN 1643
            .|.:             ...|...|:|  |...:|.:||:.|.:..::.|     .|..|..:::
Yeast    65 APSVPVTMKSAYTASSKSAYSSVKGESDIYPPPVLENSERRSVTPPKNSN-----FTSSRPSDIS 124

  Fly  1644 ---IQQREQSSQ---------LQQQAQSQTQSQ-TRSQVGNTQIERRRKVTEEFERTQSAKTIEI 1695
               .:..|::||         |.:||:....|: |.....|.:.:........||:..:..|
Yeast   125 RSISRPSERASQEDPFRFERDLDRQAEQYAASRHTCKSPANKEFQAADNFPFNFEQEDAGNT--- 186

  Fly  1696 RTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTE--RRSSYGKTGFVASQAKRLSCMEEEISSL 1758
             ...|.:|..:.....::|..|.:...|.||:|..  .....||     .|.|..|.:|.|....
Yeast   187 -EREQDLSPIERSFMMLTQNDTASVVNSMNQTDNRGVLDQKLGK-----EQQKEESSIEYESEGQ 245

  Fly  1759 TSQSQAISARASALGEGCFPNLRSPTFDSKFP--------LKPAPAESIVPGYATVPAATKMLTA 1815
            ......|.:...........||.:......||        .:|...|..|...:..|:.|  :.|
Yeast   246 QEDENDIESLNFEPDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLT--MNA 308

  Fly  1816 ------PPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVAR 1874
                  |...|...:..::|:|  .|..::::.|:..|....::...|..||.:.....:|:..:
Yeast   309 LDSKIYPDDNFSGLESSKEQKS--PGVSSSSTKVEDLSLDGLNEKRLSITSSENVETPYTATNLQ 371

  Fly  1875 SSQSLTQASAITTTTNNQATTAYRSSNGSITK--PNLASRPSIASITAPGSASAPAPVPSAAPTK 1937
            ..|.:.|...::.:.|     |....||:...  ...|||...:|....|..|...||     |:
Yeast   372 VEQLIAQLDDVSLSRN-----AKLDMNGNCLNAVDRKASRFKKSSAYLSGYPSMDIPV-----TQ 426

  Fly  1938 ATAPFKAPIVPKSVIANA---------------VNAAAPPAPAVFPPDLSDLNLN---------- 1977
            .|          |::.|:               |:..||          |:...|
Yeast   427 QT----------SIVQNSNTNLSRQTILVDKGDVDEDAP----------SESTTNGGTPIFYKFK 471

  Fly  1978 -SNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCP 2041
             |||:.|...|..|...|...........:.:|.....:|..:.||.:                .
Yeast   472 QSNVEYSNNEGMGSQETFRTKLPTIEALQLQHKRNITDLREEIDNSKS----------------N 520

  Fly  2042 DHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCL-----NAIGKHFH 2101
            |..:..||...|...|..:.|.:.   .|:.:.....| |..|..::.|..:     |.:...:|
Yeast   521 DSHVLPNGGTTRYSSDADYKETEP---IEFKYPPGEGP-CRACGLEVTGKRMFSKKENELSGQWH 581

  Fly  2102 PECFTCGQCGKIFGNR-PFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHN----Y 2161
            .|||.|.:||..|... |.::.....||:..::|...:.|..|...:|.     |.|.::    :
Yeast   582 RECFKCIECGIKFNKHVPCYILGDEPYCQKHYHEENHSICKVCSNFIEG-----ECLENDKVERF 641

  Fly  2162 HSQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192
            |..|.||..||..:....:...|..|.|.||
Yeast   642 HVDCLNCFLCKTAITNDYYIFNGEIPLCGNH 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	9/52 (17%)
		LIM	2081..2132	CDD:259829	15/56 (27%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	16/57 (28%)
PXL1	NP_013016.4	LIM1_UF1	556..614	CDD:188783	15/57 (26%)
PXL1	NP_013016.4	LIM	621..672	CDD:259829	14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		oto99545
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840