Protein Alignment Zasp52 and SYNPO2L

DIOPT Version :10

• Sequence 1: NP_001027420.2
• Gene: Zasp52 / 36740
• FlyBaseID: FBgn0265991
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001107605.1
• Gene: SYNPO2L / 79933
• HGNCID: 23532
• Length: 977
• Species: Homo sapiens
• Alignment Length: 1135
• Identity: 233/1135 - (20%)
• Similarity: 354/1135 - (31%)
• Gaps: 392/1135 - (34%)

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.:..:||.|.|:...|.:.:|||:..|.::.||.|...||.|..|..::..|||..
Human    16 PWGFRLHGGAEQRKPLQVSKIRRRSQAGRAGLRERDQLLAINGVSCTNLSHASAMSLIDASGNQL 80

  Fly    83 VITVQRGG-----STWRPH-------------VTPTGNVPQPNSP-YLQTVTKTSLAHKQQDSQH 128
            |:||||..     .:..||             ..|...||||..| .|::...:...:.:.||..
Human    81 VLTVQRLADEGPVQSPSPHELQVLSPLSPLSPEPPGAPVPQPLQPGSLRSPPDSEAYYGETDSDA 145

  Fly   129 IG-CGYNNAARPFSNGGDGGVKSIVNKQYNTPVG-----IYSDESIAETL--------------- 172
            .| .......||...|          ....||.|     :|..:|.||..
Human   146 DGPATQEKPRRPRRRG----------PTRPTPPGAPPDEVYLSDSPAEPAPTIPGPPSQGDSRVS 200

  Fly   173 -------------SAQAEVLAGGV---------------------LGVNFKKNEKEYQGDRSEVL 203
                         .|:|.:|..|.                     |...:.:..|:.:..|:|.|
Human   201 SPSWEDGAALQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAKLQRAESL 265

  Fly   204 --KFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNS 266
              |.::|.:|...|.|           ..|......:::....:.:::|:.:..|.....|...:
Human   266 QEKSIKEAKTKCRTIA-----------SLLTAAPNPHSKGVLMFKKRRQRAKKYTLVSFGAAAGT 319

  Fly   267 PKPPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDI 331
            ......|..||.::                   .|..|.|..|   .||.||..:   :..|.|:
Human   320 GAEEEDGVPPTSES-------------------ELDEEAFSDA---RSLTNQSDW---DSPYLDM 359

  Fly   332 HAKQA---AINNPPTGTEGY--------VPVPIKPNTKLSASTISSA-------LNSHGYGGHSN 378
            ...:|   |.....:|..|.        |.:..:...:..:||...|       ||..|......
Human   360 ELARAGSRASEGQGSGLGGQLSEVSGRGVQLFEQQRQRADSSTQELARVEPAAMLNGEGLQSPPR 424

  Fly   379 GYSNGNS------TPAPAPVASS---QATATVATVAPSAATAATAAATP----QAATATD---SP 427
            ..|....      :|.||||||.   |......|.|||....:....||    |..|.|.   .|
Human   425 AQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFTPGLQGQRPTTTSVIFRP 489

  Fly   428 AATASSSDNMS----------------------------AYVADEPSS--IYGQISAESVALAPP 462
            .|...::|::.                            |.|:..||:  ..|.::|.|....|.
Human   490 LAPKRANDSLGGLSPAPPPFLSSQGPTPLPSFTSGVPSHAPVSGSPSTPRSSGPVTATSSLYIPA 554

  Fly   463 PPQPPTAGGGDQPFEYVTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAAAPKSPVSYPPQQQQ 527
            |.:|.|.||..:|              .||     ||.......|..| .:||..|.:.|
Human   555 PSRPVTPGGAPEP--------------PAP-----PSAAAMTSTASIF-LSAPLRPSARP----- 594

  Fly   528 QSPRPAPGGQNPYA------TLPRSNVG-----QQGGEAVEELQPEFEEEDCYEMDIEVALAASR 581
            ::|.|.||...|.:      ::|.:..|     ::.|...:..:|..||.........::|..:.
Human   595 EAPAPGPGAPEPPSAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNL 659

  Fly   582 QSQRGSSFTWPPPQDD---------SHLAPTAAPLYIPPPETQHVVVSNPVQQVPPLPPGGATAR 637
            ..:..:......|::|         :.:.|..|..|...|   ||....|....|..||  ....
Human   660 DEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLP---HVTPKTPPPMAPKTPP--PMTP 719

  Fly   638 LDPQPVV---------------GTSANGAPQWQSYSAPQLTTASARQLAEQESSSDSYTSTSTTT 687
            ..|.||.               ..|:.|.|:     .|:|........|:::|.:|.|
Human   720 KTPPPVAPKPPSRGLLDGLVNGAASSAGIPE-----PPRLQGRGGELFAKRQSRADRY------- 772

  Fly   688 TTTSEEYQRMYAAQVQAYQMQEQSGSEFDYQVDYASTQDSVQDYPSGRRSAQECVDSLAVPLSTY 752
                                                                             
Human   773 ----------------------------------------------------------------- 772

  Fly   753 KLVDMVREVTPSPVTTP---TQTPAPAAPTTRRVVFNDEPEIKELPQL----------PAELETI 804
                 |.|.||.|...|   :.:|.|:.|.:    :...|.|:..|.:          |....|:
Human   773 -----VVEGTPGPGLGPRPRSPSPTPSLPPS----WKYSPNIRAPPPIAYNPLLSPFFPQAARTL 828

  Fly   805 PEASE---AVEDREGLVIEQRCQILESERKFQPTPEIKIEIAPVRQIPPTKIPNPM----PKEWI 862
            |:|..   ....::|:      :.|:..| .||. ::|..:....::|||  |.|:    ||...
Human   829 PKAQSQGPRATPKQGI------KALDFMR-HQPY-QLKTAMFCFDEVPPT--PGPIASGSPKTAR 883

  Fly   863 NPMIRVLTTAPEVPFHLVECPFPRPCGDDFEAEAAAAEAAKTQEVPEPL-PPQVSAAPPATVSVE 926
            ...||..:|           |.|:|..:.......|..||.|  :.||: ..::::||      .
Human   884 VQEIRRFST-----------PAPQPTAEPLAPTVLAPRAATT--LDEPIWRTELASAP------V 929

  Fly   927 PSPAPLRESPPRGSRLSQA----MVTAPEF 952
            |||||..|: |||...|.:    .|..|.|
Human   930 PSPAPPPEA-PRGLGASPSSCGFQVARPRF 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_ZASP52-like	8..88	CDD:467281	30/69 (43%)
		DUF4749	150..>218	CDD:464948	20/123 (16%)
		LIM_ALP_like	282..333	CDD:188746	10/50 (20%)
		PHA03247	<762..1006	CDD:223021	54/216 (25%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
SYNPO2L	NP_001107605.1	PDZ_SYNPO2-like	8..85	CDD:467264	29/68 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..226		26/144 (18%)
		PHA03247	<168..650	CDD:223021	103/542 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..352		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..677		70/337 (21%)
		PRK14954	<415..550	CDD:184918	30/134 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..802		28/195 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	922..950		12/34 (35%)