DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and ldb3a

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_021336348.1	Gene:	ldb3a / 794339	ZFINID:	ZDB-GENE-040121-6	Length:	746	Species:	Danio rerio

Alignment Length:	898	Identity:	229/898 - (25%)
Similarity:	337/898 - (37%)	Gaps:	260/898 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 FPPPSPLSHLTKQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVDAPKA 1440
            |..|..:|.:|...||..|.|.:.|.|                              ..:|.
Zfish    24 FNMPLTVSRITPGSKAASSNLIQGDII------------------------------VAIDG--- 55

  Fly  1441 PVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQ 1505
             |::|..|......::.:....:|.:.:|.|...|   |||.
Zfish    56 -VSTDGMTHLEAQNKIKSANFNLALTMQRSKRPTP---VPIA----------------------- 93

  Fly  1506 ALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYNELNASPFPDRTRSPAPGPPPNP 1570
                    ||.: ..|.|::|    .:|::      |||...||...|..|...:..|
Zfish    94 --------TPRI-ESPMPVIP----HQKVI------THAPANNEFLPSFNPIALKDTA------- 132

  Fly  1571 LNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQQP--ER 1633
            |:..:...:|.|..|:.|:      ..|..:..:..|....:.|.:.||....|:.....|  ||
Zfish   133 LSTNKPIEVKGPGGKATII------HAQYNTPISMYSQDAIMDAIAGQSQARGSEMSGNLPVKER 191

  Fly  1634 ITE------QRVGNLNIQQREQSSQLQQQAQSQTQS-QTRSQVGNTQI------ERRRKVTEEFE 1685
            :.:      |.|....|.|...:...::.||.|::| :..:.:..|:.      |..||..|.||
Zfish   192 VIDSASPVYQAVIPSEIDQLGPADWARRAAQLQSKSFRVLAHITGTEYMQDPDEEALRKSRERFE 256

  Fly  1686 RTQ---------------SAKTIEI-----------RTGSQSVSQSKAQSQSISQAQTQAQSQSQ 1724
            ...               ||:.:.:           ...|.|.::....|.||:.......:...
Zfish   257 SEAKGPRFAKLKNWHNGLSAQILNVPQLPFLILPLPNIVSSSAAEHAPVSTSIAPVCPPTMAALP 321

  Fly  1725 NQSDTERRSSYGKTGFVASQAKRLSCMEEEISSLTSQ---------------SQAISARASALGE 1774
            ||..:|        ..:|:||.     |.|:..:..|               ||..::.:|:..:
Zfish   322 NQLLSE--------PLIANQAP-----EPEVELIPEQTTVPSYSLQTSMGYTSQYKTSISSSYSQ 373

  Fly  1775 GCFPNLRSPTFDSKFPL--------KPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRS 1831
            .  |.::.|....:.||        :|.|.....|           :..|||  :||....||
Zfish   374 P--PPMQQPPLMQQPPLMQQPPLMQQPPPMHQHPP-----------MHQPPP--MQQPPLMQQ-- 421

  Fly  1832 AFSGYQATTSSVQQSSFASS---------SKATTSSLSSSSASASASASVARSSQSLTQASAITT 1887
                    ...:|.||....         |.||....|..:..|.|...|.:.:.......|...
Zfish   422 --------PPPMQHSSIQIPVGPPPPKVVSTATIMPASYPAGPAPAPPMVHKPAPPPPAPPAAPA 478

  Fly  1888 TTNNQATTAYRSSNGSITKPNLA-----SRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIV 1947
            :::|:...        :|..|.|     |:|:      |.:.....|:|.|||.
Zfish   479 SSSNRPPW--------VTDDNFAQKFDPSKPT------PNTNIKVQPLPQAAPP----------- 518

  Fly  1948 PKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAA- 2011
            |.|:|:|.|.||..||....||                       .|.....|...||:..:|.
Zfish   519 PPSIISNPVPAAPSPAFNPAPP-----------------------PFNPAPFPPVARGVAQRAER 560

  Fly  2012 -GPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEK 2075
             ....|.|||.:||..|||||:.||||.|.|:.|.|  ..|...|.|:.||||:.::|||.|:|:
Zfish   561 FAASNRTPLCATCNNIIRGPFLVALGRSWHPEEFNC--HYCHTSLADVSFVEEQNNVYCENCYEE 623

  Fly  2076 YLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKC 2140
            :.||||::|:.||.|:.::|:.:.:|..||.|..|||.|||..|.:|||..|||.|:..||:|||
Zfish   624 FFAPTCARCSTKIMGEVMHALRQTWHTTCFVCAACGKPFGNSLFHMEDGEPYCEKDYIALFSTKC 688

  Fly  2141 FACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNHA 2193
            ..|.|||||||:::|||.|.:|..||.|..|..|||||.||:|..:|.||.||
Zfish   689 HGCDFPVEAGDKFIEALGHTWHDTCFVCAVCHVNLEGQPFYSKKDKPLCKKHA 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	26/52 (50%)
		LIM	2081..2132	CDD:259829	23/50 (46%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	29/52 (56%)
ldb3a	XP_021336348.1	PDZ_signaling	13..82	CDD:238492	15/91 (16%)
		DUF4749	149..239	CDD:318205	19/95 (20%)
		LIM1_ZASP_Cypher	570..621	CDD:188838	26/52 (50%)
		LIM2_Enigma_like	629..680	CDD:188748	23/50 (46%)
		LIM3_ZASP_Cypher	688..742	CDD:188844	31/54 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm24287
orthoMCL	1	0.900	-	-		OOG6_109269
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950