DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zasp52 and TGFB1I1

DIOPT Version :9

Sequence 1:NP_001027420.2 Gene:Zasp52 / 36740 FlyBaseID:FBgn0265991 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001035919.1 Gene:TGFB1I1 / 7041 HGNCID:11767 Length:461 Species:Homo sapiens


Alignment Length:438 Identity:127/438 - (28%)
Similarity:180/438 - (41%) Gaps:83/438 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1784 TFDSKFPLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSF 1848
            |..|..|...||.|.        ||  :.|| |||.:              |:|..|.| .:||.
Human    13 TTTSHMPRSGAPKER--------PA--EPLT-PPPSY--------------GHQPQTGS-GESSG 51

  Fly  1849 ASSSK---------------ATTSSLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYR 1898
            ||..|               |..::...||:|......:....:.|.:.:|......::..:.:.
Human    52 ASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFP 116

  Fly  1899 SSNGSITKPNLAS------------RPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKS- 1950
            ||       .:||            |||:.|..:||       :|.|:.|.||......:...| 
Human   117 SS-------KVASGEQKEDQSEDKKRPSLPSSPSPG-------LPKASATSATLELDRLMASLSD 167

  Fly  1951 -VIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPG 2014
             .:.|.:.|:.|..    ||.:|..|..|.....|...|......|...:....||:..:|.|  
Human   168 FRVQNHLPASGPTQ----PPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKG-- 226

  Fly  2015 VRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAP 2079
                ||.|||..|.|..:|||||.|.|:||:|  |.|...|....|.|:.|..:|..|:.:..:|
Human   227 ----LCGSCNKPIAGQVVTALGRAWHPEHFVC--GGCSTALGGSSFFEKDGAPFCPECYFERFSP 285

  Fly  2080 TCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACG 2144
            .|..|...|:...:.|:|.|:|||.|.|..||:.||:..|...:|..||..|:.:||..:|..|.
Human   286 RCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQ 350

  Fly  2145 FPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192
            .|:.  |.::.||:..:|..||.|..|.....|.||:...|||.|:||
Human   351 GPIL--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zasp52NP_001027420.2 PDZ_signaling 6..87 CDD:238492
DUF4749 150..>217 CDD:292558
LIM_ALP_like 282..333 CDD:188746
LIM1_Enigma_like_1 2020..2073 CDD:188839 23/52 (44%)
LIM 2081..2132 CDD:259829 19/50 (38%)
LIM3_Enigma_like_1 2140..2193 CDD:188845 20/53 (38%)
TGFB1I1NP_001035919.1 Interaction with PTK2B/PYK2 1..240 66/276 (24%)
Transcription activation. /evidence=ECO:0000250 1..200 53/230 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87 26/99 (26%)
LD motif 1 3..15 1/1 (100%)
Interaction with PTK2/FAK1. /evidence=ECO:0000250 83..136 7/59 (12%)
Paxillin <86..>106 CDD:308898 2/19 (11%)
LD motif 2 92..104 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..152 12/49 (24%)
LD motif 3 157..168 1/10 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 172..205 10/36 (28%)
LD motif 4 203..215 1/11 (9%)
LIM1_Paxillin_like 228..280 CDD:259830 24/53 (45%)
LIM2_Paxillin_like 287..338 CDD:188723 19/50 (38%)
LIM3_Paxillin 346..398 CDD:188793 20/53 (38%)
LIM4_Leupaxin 405..456 CDD:188796
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1703
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000055
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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