DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim7

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001107560.1	Gene:	Pdlim7 / 67399	MGIID:	1914649	Length:	457	Species:	Mus musculus

Alignment Length:	478	Identity:	131/478 - (27%)
Similarity:	204/478 - (42%)	Gaps:	103/478 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1736 GKTGFVASQAKRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIV 1800
            |....:.:|.|..:| .|.:|...|::|.:.::                     |.|.....:..
Mouse    59 GSLTHIEAQNKIRAC-GERLSLGLSRAQPVQSK---------------------PQKALTPPADP 101

  Fly  1801 PGYATVPAATKMLT-----APPP--------GFLQQQ-----QQQQQRSAFSGYQATTSSVQQSS 1847
            |.|...|:|:...|     ||||        |.|.:|     .:|:.......::....:.|..|
Mouse   102 PRYTFAPSASLNKTARPFGAPPPTDSTLRQNGQLLRQPVPDASKQRLMEDTEDWRPRPGTGQSRS 166

  Fly  1848 FASSSKATTSSL--SSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLA 1910
            |...:..|.:..  .........|:.|.|     |:|.|       .|:|..:.|....|.|:..
Mouse   167 FRILAHLTGTEFMQDPDEEFMKKSSQVPR-----TEAPA-------PASTIPQESWPGPTTPSPT 219

  Fly  1911 SRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLN 1975
            |||       |.:.. ||.....||.|.           |.:....:..|.|.|         |.
Mouse   220 SRP-------PWAVD-PAFAERYAPDKT-----------STVLTRHSQPATPTP---------LQ 256

  Fly  1976 LNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWC 2040
            ..:::..:...||...|:...                   :.|:|:.|:..|||.::.|||..:.
Mouse   257 NRTSIVQAAAGGGTGGGSNNG-------------------KTPVCHQCHKIIRGRYLVALGHAYH 302

  Fly  2041 PDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECF 2105
            |:.|:|  ..|.:.|::.||.||||.::|..|::...||.|:||..||.|:.::|:...:|..||
Mouse   303 PEEFVC--SQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPNCAKCKKKITGEIMHALKMTWHVHCF 365

  Fly  2106 TCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTF 2170
            ||..|.....||.|::|:|..|||.|:.::|.|||..|.|.::||||::|||..::|..||.|..
Mouse   366 TCAACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAI 430

  Fly  2171 CKQNLEGQSFYNKGGRPFCKNHA 2193
            |:.||||::||:|..:|.||:||
Mouse   431 CQINLEGKTFYSKKDKPLCKSHA 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	20/52 (38%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	25/52 (48%)
Pdlim7	NP_001107560.1	PDZ_signaling	5..79	CDD:238492	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..166		18/104 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..226		15/59 (25%)
		LIM1_Enigma	282..333	CDD:188836	20/52 (38%)
		LIM2_Enigma	341..392	CDD:188840	21/50 (42%)
		LIM3_Enigma	400..454	CDD:188842	27/54 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839632
Domainoid	1	1.000	77	1.000	Domainoid score	I8820
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm43291
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.840