DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zasp52 and SHOX

DIOPT Version :9

Sequence 1:NP_001027420.2 Gene:Zasp52 / 36740 FlyBaseID:FBgn0265991 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_000442.1 Gene:SHOX / 6473 HGNCID:10853 Length:292 Species:Homo sapiens


Alignment Length:315 Identity:55/315 - (17%)
Similarity:106/315 - (33%) Gaps:84/315 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1593 GGPRLQTGSITTGQSYQGQL-----LAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQRE---- 1648
            ||...:..|||..:..:..|     |..|:.|.|..::.....|..:.:..|.|...:.:|    
Human    24 GGGGGKKDSITYREVLESGLARSRELGTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTA 88

  Fly  1649 -QSSQLQQQAQSQTQSQTRSQVGNTQIERRRKVT-------EEFERTQSAKTIEIRTGSQSVSQS 1705
             .:..:.:..:.:...::..:.|.|::::||..|       .|.||...    |.......:.:.
Human    89 RVAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFD----ETHYPDAFMREE 149

  Fly  1706 KAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRLSCME----EEISSLTSQSQAIS 1766
            .:|...:|:|:.|...|::.....::.:...| |.:...|..|....    ..:.:|....|.:.
Human   150 LSQRLGLSEARVQVWFQNRRAKCRKQENQMHK-GVILGTANHLDACRVAPYVNMGALRMPFQQVQ 213

  Fly  1767 ARASALGEG-CFPNLRSPTFDSKFPLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQR 1830
            |:....|.. ..|:|                      :..:.|....|..|||.|          
Human   214 AQLQLEGVAHAHPHL----------------------HPHLAAHAPYLMFPPPPF---------- 246

  Fly  1831 SAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSLTQASAI 1885
                                     ...::|.:.||||:|.||.:::|.::.|:|
Human   247 -------------------------GLPIASLAESASAAAVVAAAAKSNSKNSSI 276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zasp52NP_001027420.2 PDZ_signaling 6..87 CDD:238492
DUF4749 150..>217 CDD:292558
LIM_ALP_like 282..333 CDD:188746
LIM1_Enigma_like_1 2020..2073 CDD:188839
LIM 2081..2132 CDD:259829
LIM3_Enigma_like_1 2140..2193 CDD:188845
SHOXNP_000442.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..119 2/18 (11%)
Homeobox 120..174 CDD:395001 10/57 (18%)
SH3-binding. /evidence=ECO:0000255 242..249 4/41 (10%)
OAR 272..288 CDD:397759 2/5 (40%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 274..287 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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