DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and PDLIM2

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_067643.3	Gene:	PDLIM2 / 64236	HGNCID:	13992	Length:	602	Species:	Homo sapiens

Alignment Length:	363	Identity:	88/363 - (24%)
Similarity:	154/363 - (42%)	Gaps:	79/363 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            |||||:.||.||..|::|.||.....::.|.|:|||.:|.||......:.|.:||..:.:|.:..
Human   262 PWGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPL 326

  Fly    83 VITVQRGGSTWRP---------------------------------HVTPTGNVPQPNSPYLQTV 114
            .:.:.|..:| .|                                 :.:||...|:..||:....
Human   327 RLQLDRSQAT-SPGQTNGDSSLEVLATRFQGSVRTYTESQSSLRSSYSSPTSLSPRAGSPFSPPP 390

  Fly   115 TKTSL---AHKQQDSQHIGC--GYNNAARPFSNGGDGGVKSIVNKQYNTPVGIY--SDESIAETL 172
            :.:||   |...:..|.:.|  |...|.|...:|..|..::.:.:..::.|.:.  |....:...
Human   391 SSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLGRAGDSAVLVLPPSPGPRSSRP 455

  Fly   173 SAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQ 237
            |..:|   ||.|.::          :.|||.|.|:|...|::.|...:|.      :.||:
Human   456 SMDSE---GGSLLLD----------EDSEVFKMLQENREGRAAPRQSSSF------RLLQE---- 497

  Fly   238 YNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKP--PSTGGLPTGQNI--CTECERLITGVFVRIKD 298
                     ..:.:::..|...:.:.: ||:.  |::..|.|...:  |.:|...|....|||::
Human   498 ---------ALEAEERGGTPAFLPSSL-SPQSSLPASRALATPPKLHTCEKCSTSIANQAVRIQE 552

  Fly   299 -KNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQ 335
             :..|..|:.||.||.:||.:|::...::|||:.||:|
Human   553 GRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	25/68 (37%)
		DUF4749	150..>217	CDD:292558	14/68 (21%)
		LIM_ALP_like	282..333	CDD:188746	18/51 (35%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
PDLIM2	NP_067643.3	PDZ_signaling	259..330	CDD:238492	25/67 (37%)
		DUF4749	<462..505	CDD:292558	13/71 (18%)
		LIM_Mystique	536..588	CDD:188833	18/51 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840