DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pax6b

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_005168876.1	Gene:	pax6b / 60639	ZFINID:	ZDB-GENE-001031-1	Length:	450	Species:	Danio rerio

Alignment Length:	412	Identity:	81/412 - (19%)
Similarity:	143/412 - (34%)	Gaps:	116/412 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1501 VRPDQALTPTRP--YTPSLTNKPA------PIVPFYQTEEKLVFE-ECSATHARNYNELN----- 1551
            :|| :|:..::|  .||.:..|.|      |.:..::..::|:.| .|:..:..:.:.:|
Zfish    98 IRP-RAIGGSKPRVATPEVVGKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRN 161

  Fly  1552 -ASPFPDRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSGG-----PRLQTGSITTGQSYQG 1610
             ||   ::.:..|.|             |.:   |..:|:...|     |....|:...||..|.
Zfish   162 LAS---EKQQMGADG-------------MYD---KLRMLNGQSGTWGTRPGWYPGTSVPGQPNQD 207

  Fly  1611 QLLAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIE 1675
            ...........:.|.|.|.:....|:.|:            ||:::.|....|.|:.|:
Zfish   208 GCQQQDNGGENTNSISSNGEDSDETQMRL------------QLKRKLQRNRTSFTQEQI------ 254

  Fly  1676 RRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQ---SISQAQTQAQSQSQNQSDTERRSSYGK 1737
              ..:.:|||||...........:..:...:|:.|   |..:|:.:.:.:.:||    ||.:...
Zfish   255 --EALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQ----RRQASNS 313

  Fly  1738 TGFVASQAKRLSCMEEEISSL--TSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIV 1800
            :..:            .|||.  ||..|||            |...:|...:...:...|..::.
Zfish   314 SSHI------------PISSSFNTSVYQAI------------PQPTTPVSFTTGSMLGRPDTALT 354

  Fly  1801 PGYATVPAATKMLTAPPPGFLQQQ---QQQQQRSAFSGYQATTSSVQQSSF------------AS 1850
            ..|..:|        |.|.|....   .|..|.|::|....::.||...||            .|
Zfish   355 NTYTGLP--------PMPSFTMANNLPMQPSQTSSYSCMLPSSPSVNGRSFDTYTPPHMQAHMNS 411

  Fly  1851 SSKATTSSLSSSSASASASASV 1872
            .:.||:.:.|:...|...|..|
Zfish   412 QTMATSGTASTGLISPGVSVPV 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
pax6b	XP_005168876.1	PAX	23..160	CDD:128645	13/62 (21%)
pax6b	XP_005168876.1	Homeobox	246..298	CDD:306543	12/59 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030