Protein Alignment Zasp52 and pxnb

DIOPT Version :10

• Sequence 1: NP_001027420.2
• Gene: Zasp52 / 36740
• FlyBaseID: FBgn0265991
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: XP_021334029.1
• Gene: pxnb / 565130
• ZFINID: ZDB-GENE-130530-697
• Length: 1197
• Species: Danio rerio
• Alignment Length: 1353
• Identity: 271/1353 - (20%)
• Similarity: 431/1353 - (31%)
• Gaps: 448/1353 - (33%)

  Fly  1018 MIDLPTPKEHLSMCDALCTAPERGYTPLNPENAMHRVDEEQKQQELKKREFQVLDHEEELGIRPE 1082
            :.||.:...|:|.|...  .||.  ||.:..:......::.....|                 |.
Zfish    50 LADLESSTAHISKCPVF--LPEE--TPYSYPSGGQLFQDDSPPPPL-----------------PP 93

  Fly  1083 PPQSVEYYETRRDQPRKSSAFAAMQAFQPSREPLSSNTVSNAGSVADTPRASIVSALKEETDLEY 1147
            ||.:.....:...:|....:..::|....||:              .:|.||     :.|.|..|
Zfish    94 PPSAEALNGSLSPRPDSQQSLGSVQKSTLSRD--------------SSPPAS-----RTEEDHVY 139

  Fly  1148 QKYLKAQQRNQKRLDYFHQKEEELSGLQGQQLTQLQR---ELSNQQQNLLSQQQLQQSKLLQLQQ 1209
                 :....||..|   .....::...|..|::|.|   ||:..|||..|....:.: ...|..
Zfish   140 -----SFPNKQKHSD---SSATAMTSALGSNLSELDRLLLELNAVQQNAPSYSTTEDA-APPLPP 195

  Fly  1210 CVQSQELQQQVQH----LTQKSQQQPPQANQQQQQQQQQRGTQQQQHSQVTQRT--QQQQQQVPQ 1268
            |..:..:|:...|    ||..:|.:|           |:.||:.....:.|..:  .:.:..||.
Zfish   196 CSVAHYIQENGAHPSITLTPAAQDKP-----------QRNGTKGTDDGRPTVESLLNELESSVPS 249

  Fly  1269 ---------------QVTQQQQQEHSLLSQTTLAETQTLQA-----NAQSQSSA--SYSSK---- 1307
                           |:....:|:..:.:.:...|.:.|.|     ..||..|:  |.:|:
Zfish   250 TTPSPCALTSNLTDGQLDAPSEQQGRISATSATRELEELMACLSDFKVQSNPSSLGSLNSEPLFE 314

  Fly  1308 ------------ATACSNSSSTVPPANTSTAFAPAP----------------------------- 1331
                        .|..|.|.|...||. |..|:|.|
Zfish   315 QTTTTAEIHPPPTTTVSKSLSPTLPAE-SRQFSPGPSSFELHIVEDSGEPGAVPLPSNGVFKSYS 378

  Fly  1332 --APAPTSIP-VRP-------SAIAVQSSYCSSQFDVHELIEET--AEELEHSEVLFPPPSPLSH 1384
              :|.|.|.| ..|       |||.|.:|..||:.:...::.:|  .......:.|    ||:..
Zfish   379 RLSPPPASSPRFSPAPDLGLDSAIDVSASLLSSEVESLVVLSQTIPMTSAPRGQYL----SPVRE 439

  Fly  1385 LTKQGKAVQSGLHKAD---------SIPKYQRNWTVLPTQSPIRTPEPQEL----RENVPLAFVD 1436
            .:...|.:.|||:...         |.|...|   |....||:.||...:|    .|..||:.|.
Zfish   440 GSPSAKLMNSGLNSYSPNTKSPSPRSSPAISR---VNERVSPLMTPASIDLYLSRPETKPLSPVP 501

  Fly  1437 A-PKAPV--TSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQ-----LSVPIIVEDRSGPVTMA 1493
            : |::|:  .|:||.:..|.|....|....:|:....|...|:     |...:.::....|.|
Zfish   502 SLPRSPLPAVSESSFLSLPKALSPPPIIPTSPTLGVSKSPSPKQESAYLEPVVSLKPHLEPPT-- 564

  Fly  1494 FQP-----LDELV-----RPDQALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYN 1548
            ::|     ||:|:     ||:.....|...:..||::..|.:    .||.:|..:.|..|...:.
Zfish   565 YEPSLDDALDKLLAMSFSRPENETHITASASSQLTSEAQPEI----YEESIVAADRSDIHPDTHT 625

  Fly  1549 ELN-------------------------ASPFPDRTRSP---------------APGPPPNPLNA 1573
            |..                         |...||.:.:|               .||.|...::
Zfish   626 ESEMGDGLLEDQSDCRSDLDWADMELKMAYEGPDGSMTPMTEASWMDDSLTPSSCPGTPDAQMD- 689

  Fly  1574 IRAPRMKEPETKSNILSVSG---------------GPRLQTGSITTGQSYQGQLLAHSEQSSQSA 1623
              .|.:....|...| |.||               .|..:.|.|   :...|.|:.|...|.
Zfish   690 --LPMLHMAGTMDRI-SASGHIKSVIRRTKEIQNVHPMYRDGLI---RRKMGPLIFHKSNSQ--- 745

  Fly  1624 SQSYNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQIERRRKVTEEFERTQ 1688
                    :|:.|:..|.|.|.::|::.:.|....                     :||
Zfish   746 --------DRLIEELQGKLGIARKEKAKKQQPDDW---------------------LTE------ 775

  Fly  1689 SAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRLSCMEE 1753
                     |...:|..|             :|:..:..|.::                  .:..
Zfish   776 ---------GVIVMSNPK-------------RSREDHNRDVDK------------------IIIP 800

  Fly  1754 EISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFP----LKPAPAESIVPGYATVPAATKMLT 1814
            ..|.|..:...:..::..:     |....|..:.|.|    |.|||   :.|.....|:......
Zfish   801 PESPLPQRKMILPPQSPPM-----PRPPPPAEEPKCPPVVKLAPAP---LPPPPPPAPSPPPREP 857

  Fly  1815 APPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSL 1879
            .|||
Zfish   858 TPPP------------------------------------------------------------- 861

  Fly  1880 TQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVPSAAPTKATAPFKA 1944
                                      :|.|...|.......|....||:|.|..||..:..|..|
Zfish   862 --------------------------QPTLPPVPPKPPTPEPVVVPAPSPKPKPAPPPSPIPPPA 900

  Fly  1945 PIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNK 2009
            |:.|..|:| :|.......| :|||    |.:.:......|...|.....|:..:.....|:...
Zfish   901 PVSPPKVLA-SVGCQTEYDP-LFPP----LQIMAQGKGPHGQANKLDNMLGSLQSDLHKLGVQTV 959

  Fly  2010 AAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFE 2074
            |.|      :|.:|:..|.|..:||:||.|.|:||:|.  :|:..:....|.|.:|..|||..:.
Zfish   960 AKG------VCGACSKPIVGQVVTAMGRTWHPEHFVCT--HCQEEIGSRNFFEREGQPYCERDYH 1016

  Fly  2075 KYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTK 2139
            ...:|.|..|.|.|....:.|:.:.:|||.|.|.|||..||...|..:||.|||..|:.:||..|
Zfish  1017 HLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDLFAPK 1081

  Fly  2140 CFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192
            |..|...:.  :.::.||:..:|.:||.|..|.......||:...|:|:|:.|
Zfish  1082 CGGCARAIL--ENYISALSSLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_ZASP52-like	8..88	CDD:467281
		DUF4749	150..>218	CDD:464948
		LIM_ALP_like	282..333	CDD:188746
		PHA03247	<762..1006	CDD:223021
		LIM1_Enigma_like_1	2020..2073	CDD:188839	20/52 (38%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	15/53 (28%)
pxnb	XP_021334029.1	Paxillin	96..272	CDD:460962	38/214 (18%)
		PHA03247	<178..684	CDD:223021	106/531 (20%)
		LIM1_Paxillin_like	964..1016	CDD:259830	20/53 (38%)
		LIM2_Paxillin_like	1023..1074	CDD:188723	21/50 (42%)
		LIM3_Paxillin_like	1082..1134	CDD:188724	15/53 (28%)
		LIM4_Paxillin	1141..1192	CDD:188795