DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pdlim3b

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_005157291.1	Gene:	pdlim3b / 561865	ZFINID:	ZDB-GENE-060130-104	Length:	332	Species:	Danio rerio

Alignment Length:	363	Identity:	101/363 - (27%)
Similarity:	164/363 - (45%)	Gaps:	69/363 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||.:.:|..||.:.:..|.|||.::.|..|....:.|.:||:.:..|.|..
Zfish    12 PWGFRLSGGKDFNQPLTITRVTPGSKASRVNLCPGDIILSIQGVSTDGMTHAEAQNNIKDSTNQL 76

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGD- 145
            .:.::|..: .|.|.|...|.|    :|:     |.:|..::||..:....:|...:||::...
Zfish    77 FLKIERPETKIWSPQVIEEGKV----NPF-----KINLEAEKQDIDYFEHKFNVRPKPFTSASQR 132

  Fly   146 ---------GGVKSIV-------NKQYNTPVGIYSDESIAETLSAQAEVLAGGVLGVNFKKNEKE 194
                     |.|..:.       :.|||:||.:||.::::.||.
Zfish   133 SDSTSQTLMGNVAQMAGTPSTAHSVQYNSPVALYSADNVSNTLQ--------------------- 176

  Fly   195 YQGDRSEVLKFLREEETGQSTP--AFGNSH-YE--HDAPQQLQQPQQQYNQHQQHYHQQQQQQQS 254
             |...|.|::    :.:..|.|  :..:|| |.  .||.:|..:|:|..:......:.:....:.
Zfish   177 -QAQMSTVVR----QASPSSKPLTSIEDSHVYRMLQDANEQPHEPRQSGSFKALQDYVESDGTRP 236

  Fly   255 STTRHVSAPVNSPKPPSTG--GLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKN 317
            ..||.|.|||..|:..::.  .||    :|.:|...|.|..|:.:||..|..||.|:.||.:||.
Zfish   237 MVTRSVKAPVTKPQAATSSLQKLP----LCDKCGTGIVGTVVKARDKYRHPACFVCSDCGMNLKQ 297

  Fly   318 QGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIKP 355
            :||:..:.::||:.||:...  .||   ||:..|.:.|
Zfish   298 KGYFFVDGQMYCEAHARMRM--TPP---EGHDLVTVYP 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	27/68 (40%)
		DUF4749	150..>217	CDD:292558	14/75 (19%)
		LIM_ALP_like	282..333	CDD:188746	19/50 (38%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
pdlim3b	XP_005157291.1	PDZ_signaling	2..81	CDD:238492	27/68 (40%)
		DUF4749	156..232	CDD:292558	22/101 (22%)
		LIM_ALP	262..314	CDD:188834	20/51 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9898
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940