DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and lpxn

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_689239.4	Gene:	lpxn / 560743	ZFINID:	ZDB-GENE-081105-159	Length:	405	Species:	Danio rerio

Alignment Length:	359	Identity:	100/359 - (27%)
Similarity:	145/359 - (40%)	Gaps:	72/359 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1876 SQSLTQAS------AITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSA-SAPAPVPSA 1933
            :|:.::||      ...|..||..|...::.:.|:             |..|... ..|..||
Zfish    12 AQNSSEASDPPVLLPAKTLKNNNTTVLQQTESSSL-------------IAGPRQTFDNPYSVP-- 61

  Fly  1934 APTKATAPFKAPIVPKSVIANAVNA-----------AAPPAPAVFPPDLSDLNLNSNVDNSPGAG 1987
                 |||.:|.::........:::           .:.|||:..||.|:..::.:......|..
Zfish    62 -----TAPVEASLMSPRTATRELDSLMNDLLGLDLEVSEPAPSSNPPPLARKSIKAKTTEETGES 121

  Fly  1988 GK------------------SAGA------FGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIR 2028
            |.                  |.|.      .|:.|:.....|:...|.|.      |.||...|.
Zfish   122 GSGRQEGDRKPQHPPLSEKFSKGVDAIDDLLGSLSSDMEKMGVRTAAKGH------CASCGKCIA 180

  Fly  2029 GPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCL 2093
            |..|||||::|.|:||:|  ..||..|...||.|..|..|||..::|..:|.|:.|.|.|..:.|
Zfish   181 GKMITALGQVWHPEHFVC--SACREELGTCGFFERDGKPYCEKDYQKLFSPRCAYCKGPITQNIL 243

  Fly  2094 NAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALN 2158
            .|:.:.:|||.|.|..||.:||...:...||..||..|:..||..||..||.||:  :.::.|.|
Zfish   244 TAMDQTWHPEHFFCCHCGDLFGPEGYLERDGKPYCSRDFYCLFAPKCSGCGEPVK--ENYLSAAN 306

  Fly  2159 HNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192
            ..:|..||.|:.|.:......|....|||.|..|
Zfish   307 GTWHPDCFVCSDCLKPFTDGCFLELNGRPLCSLH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	25/52 (48%)
		LIM	2081..2132	CDD:259829	19/50 (38%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	18/53 (34%)
lpxn	XP_689239.4	LIM1_Paxillin_like	172..224	CDD:259830	25/53 (47%)
		LIM2_Leupaxin	231..282	CDD:188792	19/50 (38%)
		LIM3_Leupaxin	290..342	CDD:188794	18/53 (34%)
		LIM4_Leupaxin	349..400	CDD:188796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810