DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pdlim2

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001313331.1	Gene:	pdlim2 / 560322	ZFINID:	ZDB-GENE-070308-4	Length:	364	Species:	Danio rerio

Alignment Length:	372	Identity:	91/372 - (24%)
Similarity:	151/372 - (40%)	Gaps:	91/372 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            |||||:.||.||.:.:.|.||||||.:|.|.|||||.:::||.:....:.:.:||:.:.......
Zfish    13 PWGFRISGGRDFKKAITVSKVNAGSKAETACLQPGDIIMEINGLSAGEMLNVEAQNKIKCCTTQL 77

  Fly    83 VITVQR---------GGSTWR---------------------------PHVTPTGNVPQ-PNSPY 110
            .:.|:|         .|.|.:                           ..::|....|: |:||.
Zfish    78 QLLVERPAPPTPGQTNGITEQLVGRFQEAVQVSRDENQNYKEYTISSPASLSPGPYTPEPPSSPD 142

  Fly   111 LQ----TVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDGGVKSI------VNKQYNTPVGIYSD 165
            .:    |.|..||......|:......:..:||.|.    ...|:      |:.:..||.|.||.
Zfish   143 RRGGRITPTNKSLQFHSWSSEEKNVQSHRLSRPLSQ----EFSSLDFRSNCVSSRTPTPPGQYSP 203

  Fly   166 ESIAETLSAQAEVLAGGVLGVNFKKNE----KEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHD 226
            .|..|.           .|.|:.:::.    :::..| |||.|.::|.:..::.|
Zfish   204 HSPIER-----------ELSVSPRRSSDFAMQKFDRD-SEVYKMIQENKESRAAP---------- 246

  Fly   227 APQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQ--NICTECERLI 289
                     :|.|..:......:..::.:..|..|.  .||.||.|..:...|  :.|.:|...|
Zfish   247 ---------RQSNTFKMLQEVLEADEKEAALRFPSK--LSPNPPKTSSVAGVQKHHTCEKCGTSI 300

  Fly   290 TGVFVRIKDK-NLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQ 335
            ....|:|.|. ..|.||:.|..||.:||.:|::...:|::|:.||::
Zfish   301 VTQAVKITDNCYRHPECYTCTECGLNLKMRGHFWAEDKMFCEKHARE 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	27/68 (40%)
		DUF4749	150..>217	CDD:292558	17/76 (22%)
		LIM_ALP_like	282..333	CDD:188746	17/51 (33%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
pdlim2	NP_001313331.1	PDZ_signaling	3..82	CDD:238492	27/68 (40%)
		DUF4749	<226..264	CDD:292558	9/57 (16%)
		LIM_Mystique	293..345	CDD:188833	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583714
Domainoid	1	1.000	66	1.000	Domainoid score	I9898
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840