DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pdlim3a

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001019547.1	Gene:	pdlim3a / 554148	ZFINID:	ZDB-GENE-050505-1	Length:	307	Species:	Danio rerio

Alignment Length:	329	Identity:	98/329 - (29%)
Similarity:	162/329 - (49%)	Gaps:	42/329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||:|||.|.|::.||.:....|.|||.::.|:.|...||.|.:||.::..:....
Zfish    12 PWGFRLIGGRDFSQPLTVAKISPGSKASTVNLSPGDIILSIDGVSAENLMHSEAQTLIKDASYQL 76

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGD- 145
            .:||:|..: .|.|::|       .::|:     |.:|..::|:.:.||.|:|..|.||....:
Zfish    77 TLTVERPETKLWSPNMT-------EDNPF-----KMNLEAERQEHRPIGAGHNRRASPFVAAANI 129

  Fly   146 GGVKSIVNKQYNTPVGIYSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEE 210
            ...:.:|:..||:|:|:||..:|.:.|..|.:    |::....:...|....:.|:|.:.|::.:
Zfish   130 DETRQVVSPTYNSPIGLYSSGNIQDALQGQLK----GLIHNKAESPTKLSNIEDSDVYRMLQKNQ 190

  Fly   211 TGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTG-- 273
                         |.|   :..:|:|..:..........:..:....|.|.||::.|..||..
Zfish   191 -------------EED---EAHEPRQSGSFKALQSFMNSEGTRPLVIRKVHAPMSKPSAPSGNLH 239

  Fly   274 GLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAI 338
            .||    :|.:|...|.|..|:::||..|.:||.|..|..:||.:|||..:::|||:.||...|
Zfish   240 KLP----MCDKCGNGIVGTVVKVQDKFRHPDCFVCTECEENLKQKGYYFIDDELYCESHAHARA- 299

  Fly   339 NNPP 342
             .||
Zfish   300 -KPP 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	29/68 (43%)
		DUF4749	150..>217	CDD:292558	15/66 (23%)
		LIM_ALP_like	282..333	CDD:188746	20/50 (40%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
pdlim3a	NP_001019547.1	PDZ_signaling	2..81	CDD:238492	29/68 (43%)
		DUF4749	134..214	CDD:292558	19/99 (19%)
		LIM_ALP_like	244..295	CDD:188746	20/50 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9898
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910