DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and pdlim5

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_012817118.2	Gene:	pdlim5 / 548530	XenbaseID:	XB-GENE-854114	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	921	Identity:	248/921 - (26%)
Similarity:	374/921 - (40%)	Gaps:	211/921 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1382 LSHLTKQGK------AVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVD--AP 1438
            ::||..|.|      ::...|.:|.:.||...|        |.:|..|:|:.:.||:|...  ||
Frog    61 MTHLEAQNKIKACTGSLNLTLQRASAAPKANPN--------PPQTETPKEIIKPVPIASPTPVAP 117

  Fly  1439 --------KAPVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQ 1495
                    |||....|:|..:| |.:.:.::...|:       ...||:      :|.|...|..
Frog   118 KVSNVAYNKAPKPFGSATSSKP-ASIPSASSAFTPA-------SASLSI------QSSPQPSALS 168

  Fly  1496 PLDELVRPDQAL--------TPTRPYTPSLT-NKPAPIVP-----FYQT----EEKLVFEECSAT 1542
            .|.::..|..:.        |....:.|:|: .|||..||     :.||    :.::..:.....
Frog   169 LLAQVGPPPNSAPGLHANSKTTIEGHLPALSATKPAVNVPRQPASYSQTANLYDNEVAQDGAEVR 233

  Fly  1543 HARNYNELNASPFPDRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSG-------------- 1593
            ..:..|:      .|:.:: ...||..|      ||....:|.::|...|.
Frog   234 RGQKENQ------GDKHQN-GKIPPKRP------PRKHIVDTYTDIYHTSAYSDASKKRLIDNTE 285

  Fly  1594 --GPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQREQSS----- 1651
              .||  ||   |.||...::||      |.....:..:||....|:....||...:.|:
Frog   286 DWHPR--TG---TTQSRSFRILA------QMTGTEHMSEPEPENVQKTKESNICNGDISTSAESP 339

  Fly  1652 ------QLQQQAQS-QTQSQTRSQVGNTQI-----ERRRKVTEEFERTQSAKTIEIRTGSQSVSQ 1704
                  :|.|.|:: ...:||...|.:..:     ||......|.|.|....:........:|..
Frog   340 NGREDRKLSQNAEACSVATQTDVPVEDVTLILDLSERPEPALLEREETYFVSSCRTSPEKSAVQT 404

  Fly  1705 SKAQS------------QSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQAKRL---SCMEEE 1754
            |.:||            :|:.:|.....:..|......:.::..||..|..::..:   |.:|..
Frog   405 SPSQSPHRRKSLFDNPLESLPKAAPFPPATVQILKVNSQVATIAKTASVYMRSSMVIPDSLLENS 469

  Fly  1755 ISSLT---SQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPA-------ESIVPGYATVP-- 1807
            .|:.|   .....|:|:     |.|  ::.:.|.|.  .|.||.:       .|::|....||
Frog   470 SSAATVINGTGTKINAK-----EKC--SIATQTCDK--VLIPASSPCAVEYIASVIPSTPQVPPR 525

  Fly  1808 ---AATKMLTAP-----PPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSA 1864
               ||..:.|.|     ||..|.....|..:|..|...|.|:.|     .:.::.:...:|.|..
Frog   526 QYIAANPLDTLPKCAPCPPPVLAPLTIQTCKSKVSAVAAVTAIV-----GAQARLSDPFVSRSLL 585

  Fly  1865 SASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIA--SITAPGSASAP 1927
            .|...:.:.:||   ...|..|..:.....|.:..||.|:..|     |:.|  |...|.|..:|
Frog   586 DALLISPIPKSS---FPTSKPTRKSTGGLYTGHNHSNVSVEVP-----PATATSSKIMPSSYKSP 642

  Fly  1928 APVPSAAPTKATAPFKAPIVPKS--VIANAVNAAAPPA--PAVFPPDLSDLN-LNSNVDNSPGAG 1987
               ||:.|. .:.|.....||.|  |..||.||..|.|  .:|.||.:.|.: |....::.|.
Frog   643 ---PSSKPV-TSKPTGWQTVPSSGQVTNNASNAVKPVANNKSVPPPWIEDQDTLVQRAEHIPA-- 701

  Fly  1988 GKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCR 2052
                                      |.|.|:|..||..|||||:.|||:.|.|:.|.|  .:|:
Frog   702 --------------------------GTRTPMCAICNKVIRGPFLLALGKSWHPEEFNC--AHCK 738

  Fly  2053 RPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNR 2117
            ..:.::|||||||.||||.|:||..||.|::|..||.|:.:||:.:.:|..||.|..|.....|.
Frog   739 SSMAEMGFVEEKGGLYCEICYEKLFAPECARCQRKILGEVINALKQTWHVSCFVCVACQTPIRNS 803

  Fly  2118 PFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYN 2182
            .|.||||..|||.|:..||.|.|..|.||:|||||::|||.|.:|:.||.||.|.:|||||:|::
Frog   804 VFHLEDGEPYCETDYYSLFGTICHGCEFPIEAGDRFLEALGHTWHNTCFVCTICCENLEGQTFFS 868

  Fly  2183 KGGRPFCKNHA 2193
            |..:..||.||
Frog   869 KKDKLLCKKHA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	27/52 (52%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	28/52 (54%)
pdlim5	XP_012817118.2	PDZ	10..83	CDD:214570	5/21 (24%)
		PRK14951	<80..216	CDD:237865	37/157 (24%)
		DUF4749	212..320	CDD:406377	24/131 (18%)
		LIM1_ENH	708..759	CDD:188837	27/52 (52%)
		LIM2_Enigma_like	767..818	CDD:188748	21/50 (42%)
		LIM3_ENH	826..880	CDD:188843	30/54 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm48439
Panther	1	1.100	-	-	LDO	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.050