DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_058557.2	Gene:	Pdlim1 / 54132	MGIID:	1860611	Length:	327	Species:	Mus musculus

Alignment Length:	356	Identity:	111/356 - (31%)
Similarity:	166/356 - (46%)	Gaps:	64/356 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||.:.:|..||.:..|.|..||.:..|:..|..::.|.:||:.:....:|.
Mouse    13 PWGFRLVGGKDFEQPLAISRVTPGSKAAIANLCIGDLITAIDGEDTSSMTHLEAQNKIKGCADNM 77

  Fly    83 VITVQRG-GSTWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDG 146
            .:||.|. ...|.|.||..|.    ..||     |.:||.:.|:..|||..:|.:|.||:.....
Mouse    78 TLTVSRSEQKIWSPLVTEEGK----RHPY-----KMNLASEPQEVLHIGSAHNRSAMPFTASPAP 133

  Fly   147 GVKSIVNKQYNTPVGIYSDESIAETLSA-QAEVLAGGVLGVNFKKNEKEYQG----DR-SEVLKF 205
            ..:.|.| |||:|.|:||.|:|:...:| :::..|.|....:....:....|    |: |||.|.
Mouse   134 STRVITN-QYNSPTGLYSSENISNFNNAVESKTSASGEEANSRPVVQPHPSGSLIIDKDSEVYKM 197

  Fly   206 LREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYN-----QHQQHYHQQQQQQQSSTTRHVSAPV- 264
            |:|:                   |:|.:|.:|..     |.......:....:.|..|.|.|||
Mouse   198 LQEK-------------------QELNEPPKQSTSFLVLQEILESDGKGDPNKPSGFRSVKAPVT 243

  Fly   265 -------NSPKPPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYN 322
                   |:.|.|          ||.:|...|.||||:::|.:.|.||:.|..||.:||.:|::.
Mouse   244 KVAASVGNAQKLP----------ICDKCGTGIVGVFVKLRDHHRHPECYVCTDCGINLKQKGHFF 298

  Fly   323 FNNKLYCDIHAKQAAINNPPTGTEGYVPVPI 353
            ..:::||:.||::..  .||   |||..|.:
Mouse   299 VEDQIYCEKHARERV--TPP---EGYDVVTV 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	27/68 (40%)
		DUF4749	150..>217	CDD:292558	22/72 (31%)
		LIM_ALP_like	282..333	CDD:188746	19/50 (38%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Pdlim1	NP_058557.2	PDZ_signaling	5..81	CDD:238492	26/67 (39%)
		DUF4749	136..228	CDD:292558	27/111 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..184		2/22 (9%)
		LIM_CLP36	258..309	CDD:188832	19/50 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839627
Domainoid	1	1.000	61	1.000	Domainoid score	I10388
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870