DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim3

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001361581.1	Gene:	Pdlim3 / 53318	MGIID:	1859274	Length:	364	Species:	Mus musculus

Alignment Length:	396	Identity:	109/396 - (27%)
Similarity:	160/396 - (40%)	Gaps:	103/396 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||::.::..||.:..|.|.|||.::.|:.....::.|.||||.:..:....
Mouse    12 PWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAASYQL 76

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPF-----S 141
            .:.:.|..: .|.|.|:..|..    .|:     |.:|..:.||..:....:|...:||     :
Mouse    77 CLKIDRAETRLWSPQVSEDGKA----HPF-----KINLEAEPQDVNYFEHKHNIRPKPFIIPGRT 132

  Fly   142 NG---------GDG-----------------------------------GVKSIVNKQYNTPVGI 162
            :|         |.|                                   ||| ||:.|:|||:.:
Mouse   133 SGCSTPSGVDCGSGRSTPSSVSTVSTICPGDLKVAAKMAPNIPLEMELPGVK-IVHAQFNTPMQL 196

  Fly   163 YSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQ-GDRSEVLKFLREEETGQSTPAFGNS----- 221
            |||::|.|||..|...    .||.....:|.... ..:|:|.:.|.:.....:.|....|
Mouse   197 YSDDNIMETLQGQVAT----ALGETSSMSEPTASVPPQSDVYRMLHDNRDDPAAPRQSGSFRVLQ 257

  Fly   222 HYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQN--ICTE 284
            ...:|.|                      ..:.:.||.|.|||....    ||..:.|.  :|.:
Mouse   258 DLVNDGP----------------------DDRPAGTRSVRAPVTKVH----GGAGSAQRMPLCDK 296

  Fly   285 CERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYV 349
            |...|.|..|:.:||..|.|||.||.|..:||.:||:....:|||:.||:  |...||   |||.
Mouse   297 CGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFVEGELYCETHAR--ARTRPP---EGYD 356

  Fly   350 PVPIKP 355
            .|.:.|
Mouse   357 TVTLYP 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	26/68 (38%)
		DUF4749	150..>217	CDD:292558	20/67 (30%)
		LIM_ALP_like	282..333	CDD:188746	21/50 (42%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Pdlim3	NP_001361581.1	PDZ_signaling	2..80	CDD:238492	26/67 (39%)
		DUF4749	184..268	CDD:374237	25/110 (23%)
		LIM_ALP	294..346	CDD:188834	22/51 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10388
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940