DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and ldb3

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_017950805.1	Gene:	ldb3 / 394699	XenbaseID:	XB-GENE-922381	Length:	818	Species:	Xenopus tropicalis

Alignment Length:	938	Identity:	231/938 - (24%)
Similarity:	355/938 - (37%)	Gaps:	267/938 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 FPPPSPLSHLTKQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVDAPKA 1440
            |..|..:|.:|...||.||.:::.|.:                              ..:|.
Frog    23 FNMPLTISRVTPGSKAAQSSVNQGDLV------------------------------VAIDG--- 54

  Fly  1441 PVTSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQ 1505
             |.:|..| |             ..::.:.|.....|.:.:....|.|||..|
Frog    55 -VNTDGMT-H-------------LEAQNKIKSASYNLGLTLQKSKRPGPVPTA------------ 92

  Fly  1506 ALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSATHARNYNELNASPFPDRT-------RSPA 1563
                    ||.: :.|.|::| :|.:..|              |:|.|    ||       :|..
Frog    93 --------TPRM-DSPMPVIP-HQKDHAL--------------EINGS----RTAYSTVSSKSAV 129

  Fly  1564 PGPPPNPLNAIRAPRMKEPET----KSNILSVSGGPRLQTGSITTGQS-YQGQLLAHSEQSSQSA 1623
            |.......|...|..:.:.||    .|..:..|....:.|.|:.:..| .:|.:.:..:.....|
Frog   130 PLVGSMSTNETMAGYVSKQETNHSHSSTFIKTSVRTSMSTHSVASDASPIKGSIGSKVDPLVSGA 194

  Fly  1624 SQSYNQ---QPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQ-----IERRRKV 1680
            :...||   ...|:....||..:.:...:.:::.:.:.....|:.....||..     ::....|
Frog   195 NNPINQFSPSKNRLYNNPVGLYSAETLNEMAEMHKLSLKGRASEGGLHRGNLPVKDPLVDIASPV 259

  Fly  1681 TEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYGKTGFVASQA 1745
            .:...:.|.....||...::..:..:::|..:....|..:.......|..||:|
Frog   260 YQAVLKNQGKTESEIDDWARRAANLQSKSFRVLAHITGTEYMQDPDEDALRRAS----------- 313

  Fly  1746 KRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFD-------SKFPLKPAPAESIVPGY 1803
                         :.::.|.|...|..|....|:.||.|:.       ...|.:|:|..|  .||
Frog   314 -------------SKENVAKSPEISPAGAKVLPSARSGTWHPTKSPTREDIPSQPSPVSS--RGY 363

  Fly  1804 A------TVPAAT-------KMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKAT 1855
            :      :||...       .:....||                    .||:.:::..|:|..|:
Frog   364 SVRFGGDSVPRKNVHTSTDQNLPKLSPP--------------------ITSTYKRAPAAASISAS 408

  Fly  1856 TSSLSSS---SASASASASVARSSQSLTQASAITTTTNNQATTAYRSSN--------GSITKPNL 1909
            ..:...|   |.:||..:|...:..|..|.|:.|||..::|:.::.||.        |:.::|..
Frog   409 QKTFQGSKNMSIAASTISSAISAQSSHQQQSSFTTTYQSKASQSFSSSTTAKGPVPYGAYSEPAA 473

  Fly  1910 A--------SRPSIASITAPGSASAPA---PVP---------SAAP----------TKAT----- 1939
            .        |.|:.......|..|.||   |||         |:||          |.|:
Frog   474 KGPVPYGGYSEPAAKGPVPYGGYSEPAAKGPVPYGGYSEPAASSAPAAPAPKPRVVTTASIKPSV 538

  Fly  1940 -----APFKAPIVPKSVIANAVNAAAPPA--PAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGAT 1997
                 ||...|:.|.:.|      .|||.  |:..||.::|.|.:...     |.|||.......
Frog   539 YQPSQAPAPGPVQPPAQI------YAPPTQEPSNRPPWVTDDNFSQKF-----APGKSTSTVTKQ 592

  Fly  1998 SAPKRG-------------------------RGILNKAA--GPGVRIPLCNSCNVQIRGPFITAL 2035
            ..||..                         ||::.:|.  ....|.|||.|||..|||||:.|:
Frog   593 ILPKAAPLPPTPISAPSYTPQPVGQSPSQVPRGLIQRAERFPASSRTPLCASCNSIIRGPFLVAM 657

  Fly  2036 GRIWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHF 2100
            ||.|.|:.|.|  .:|:..|.|:.||||:..:|||.|:|::.||||::|..||.|:.::|:.:.:
Frog   658 GRSWHPEEFNC--AHCKTSLADVSFVEEQKGVYCERCYEQFFAPTCARCNTKIMGEVMHALRQTW 720

  Fly  2101 HPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQC 2165
            |..||.|..|.|.|||..|.:|||..|||.|:..||:|||..|.|||||||:::|||.|.:|..|
Frog   721 HTTCFVCAACRKPFGNSLFHMEDGEPYCEKDYVALFSTKCHGCDFPVEAGDKFIEALGHTWHDTC 785

  Fly  2166 FNCTFCKQNLEGQSFYNKGGRPFCKNHA 2193
            |.|..|..|||||.||:|..:|.||.||
Frog   786 FICAVCHVNLEGQPFYSKKDKPLCKKHA 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	26/52 (50%)
		LIM	2081..2132	CDD:259829	22/50 (44%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	29/52 (56%)
ldb3	XP_017950805.1	PDZ_signaling	8..81	CDD:238492	16/105 (15%)
		DUF4749	209..310	CDD:406377	12/100 (12%)
		gliding_GltJ	<462..>640	CDD:411345	39/188 (21%)
		LIM1_ZASP_Cypher	642..693	CDD:188838	26/52 (50%)
		LIM2_Enigma_like	701..752	CDD:188748	22/50 (44%)
		LIM3_Enigma_like	760..813	CDD:188749	29/52 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm48439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920