DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pdlim1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_017950803.1	Gene:	pdlim1 / 394527	XenbaseID:	XB-GENE-1004691	Length:	345	Species:	Xenopus tropicalis

Alignment Length:	370	Identity:	115/370 - (31%)
Similarity:	168/370 - (45%)	Gaps:	70/370 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||.:.:|..||.:..|.|..||.|:.|:..:...:.|.:||:.:....:..
Frog    13 PWGFRLIGGKDFDQPLTISRVMPGSKAAVADLCIGDVVISIDGENTDGMTHLEAQNKIKGCEDEL 77

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPFSNGGDG 146
            ::|:.|..| .|.|.|:..|   :|| ||     |.:||...|:.:.||..:|.:|.||:.....
Frog    78 ILTINRVESKIWSPLVSEDG---KPN-PY-----KMNLASNPQELKQIGSAHNRSAMPFTAASAS 133

  Fly   147 GVKSIVNKQYNTPVGIYSDESI---------AETLSAQAEVLAG-GVLGVNFKKNEKEYQGDRSE 201
            ....::..|||.|.|:||.::|         ..|.|||....|. .....|.:..:||     ||
Frog   134 STPKVITAQYNNPAGLYSSDNIENFNSALETKSTPSAQVPSKASEPTQPANTRHLDKE-----SE 193

  Fly   202 VLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQH--QQHYHQQQQQQQSSTTRHVSAPV 264
            |.|.|:|.                   |:|.:|.:|....  .|...:..::....|....:.|:
Frog   194 VYKMLQEN-------------------QELDEPPRQSASFLVLQEILETDEKDFEGTECLYTGPM 239

  Fly   265 NSP------KP--------PST---GGLPTGQN--ICTECERLITGVFVRIKDKNLHVECFKCAT 310
            ..|      ||        |:|   ..|.:||.  ||..|...|.||||:|:||..|.||:.|..
Frog   240 ERPFIDAGEKPSGFRSVRAPTTKVAASLGSGQKLPICGHCGSGIVGVFVKIRDKPHHPECYVCTD 304

  Fly   311 CGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIKP 355
            ||.:||.:|::...:|:||:.||::..  .||   |||..|.:.|
Frog   305 CGMNLKQKGHFFVEDKMYCEKHARERM--TPP---EGYDVVTVFP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	26/68 (38%)
		DUF4749	150..>217	CDD:292558	22/76 (29%)
		LIM_ALP_like	282..333	CDD:188746	22/50 (44%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
pdlim1	XP_017950803.1	PDZ_signaling	5..81	CDD:238492	25/67 (37%)
		DUF4749	137..225	CDD:374237	27/111 (24%)
		LIM_CLP36	276..327	CDD:188832	22/50 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10821
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.040