DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and pdlim5b

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_956490.1	Gene:	pdlim5b / 393165	ZFINID:	ZDB-GENE-040426-908	Length:	628	Species:	Danio rerio

Alignment Length:	847	Identity:	205/847 - (24%)
Similarity:	299/847 - (35%)	Gaps:	277/847 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 FPPPSPLSHLTKQGKAVQSGLHKADSIPK----YQRNWTVLPTQSPIR----------------- 1419
            |..|..:|.||..|||.::.:...|.:..    :....|.|..|:.|:
Zfish    25 FSMPLTISKLTDGGKAAKAKISVGDVVLSIDGIHTEGMTHLEAQNKIKACSGNLNLSLMRPSSVI 89

  Fly  1420 ---TP--EPQELRENVPLAFVDA-PKAPV--TSDSSTVHRPIAQVAAPTTVVAPSREREKERRPQ 1476
               ||  ||.|:.:.||::...| ..:||  |...:...||..........|:||     ...|:
Zfish    90 KVETPKEEPLEIIKPVPISQTPASASSPVGLTPAYNKTARPFGGATNTVRSVSPS-----PAAPK 149

  Fly  1477 LSVPIIVEDRSGPVTMAFQPLDELVRPDQALTPTRPYTPSLTNKPAPIVPFYQTEEKLVFEECSA 1541
            .|:|        ..:.||.|    ..|.|  .|.:|        |.|:....|
Zfish   150 ASIP--------SASSAFTP----AAPSQ--QPPQP--------PFPLAGSAQ------------ 180

  Fly  1542 THARNYNELNASPFPDRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQ 1606
                     .:.|.|:...|||....|.|.:. |:|
Zfish   181 ---------RSQPSPNSISSPASNSAPKPSSG-RSP----------------------------- 206

  Fly  1607 SYQGQLLAHSEQSSQSASQSYNQQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGN 1671
                  .|:|..:|.|.|.|    |.|:|                 ....|.....:...|.|.|
Zfish   207 ------FANSSSASSSGSSS----PARVT-----------------APAPAPPPASATPHSSVYN 244

  Fly  1672 TQIERRRKVTEEFERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSDTERRSSYG 1736
            |.|                         ...|...|...::.|.:...:|:.:.|:.|.|:
Zfish   245 TPI-------------------------SLYSNQNACEVAMGQRRGLMESKGEQQNGTARK---- 280

  Fly  1737 KTGFVASQAKRLSCMEEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKFPLKPAPAESIVP 1801
                        ..:|.|::.::..|.|...|           |...|            |...|
Zfish   281 ------------PVLETEVNHVSPLSDASKKR-----------LIEDT------------EDWHP 310

  Fly  1802 GYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASA 1866
            ...|..:.:..:.|...| .:..|.|:.|   .|.......:|.||.:|||..|   :|.|.|.|
Zfish   311 RTGTTQSRSFRILAQITG-TENDQAQESR---PGKNEAVEDLQPSSHSSSSVFT---MSKSPAGA 368

  Fly  1867 SASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVP 1931
            :      |....::.|.|....|::.::..:..|.|:
Zfish   369 T------RQGNGISAAPAKHWQTSSSSSAGFPRSGGA---------------------------- 399

  Fly  1932 SAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGA 1996
            ..|||       .|.|.:.|.::.......|.|...|.| .|.::....::.|.
Zfish   400 GVAPT-------GPSVGRGVSSSVPKGPERPVPQPHPRD-QDESVVQRAEHMPA----------- 445

  Fly  1997 TSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFV 2061
                             |.|.|:|..||..|||||:.|:|:.|..|.|.|  .:||..|.|:|||
Zfish   446 -----------------GTRTPMCAHCNTVIRGPFLVAMGKSWHKDEFTC--SHCRSSLADVGFV 491

  Fly  2062 EEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNA 2126
            ||:|.:||..|:|::|||||.:|..||.|:.:||:.:.:|..||.|..|.:..||..|.|||...
Zfish   492 EERGSVYCVLCYEEFLAPTCFQCHKKIIGEVINALKQTWHVNCFLCASCKQPIGNNTFHLEDRQP 556

  Fly  2127 YCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKN 2191
            |||.|:..||.|.|..|.||:||||:::|||...:|..||.|..|..:||||:|::|..:|.||.
Zfish   557 YCEKDYYSLFGTGCHGCDFPIEAGDKFLEALGFTWHDTCFVCAVCSTSLEGQTFFSKKDKPLCKK 621

  Fly  2192 HA 2193
            ||
Zfish   622 HA 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	26/52 (50%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	25/52 (48%)
pdlim5b	NP_956490.1	PDZ_signaling	11..80	CDD:238492	13/54 (24%)
		DUF4749	243..335	CDD:292558	23/156 (15%)
		LIM1_Enigma_like	452..503	CDD:188747	26/52 (50%)
		LIM2_Enigma_like	511..562	CDD:188748	21/50 (42%)
		LIM	570..624	CDD:295319	27/54 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583716
Domainoid	1	1.000	77	1.000	Domainoid score	I8757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm24287
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950