DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Sox14

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	143/755 - (18%)
Similarity:	236/755 - (31%)	Gaps:	263/755 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1313 NSSSTVPPANTSTAFAPAPAPAPTSIPVRPSAIAVQSSYCSSQFDVHELIEETAEELEHSEVLF- 1376
            |.::|.||.:......|.   .|.:.|.||:.|.:|..:.:.:          |:...|:...|
  Fly     6 NQATTEPPLSLRPGTVPT---VPATTPARPATITIQRRHPAPK----------ADSTPHTLPPFS 57

  Fly  1377 PPPSPLSHLTKQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRE------------- 1428
            |.|||.|.                            |:.:|.:||..|:.:.
  Fly    58 PSPSPASS----------------------------PSPAPAQTPGAQKTQSQAAITHPAAVASP 94

  Fly  1429 NVPLAFVDAPKAPVTSDSSTVH---RPIAQVAAPTTVVAPSREREK--ERRPQLSVPIIVEDRSG 1488
            :.|:| ..|||.|.|.:..:.|   ...:|..:|     |.||.|.  ||.|         ..||
  Fly    95 SAPVA-AAAPKTPKTPEPRSTHTHTHTHSQHFSP-----PPRESEMDGERSP---------SHSG 144

  Fly  1489 -PVTMAFQPLDELVRPDQALTPTRPYTP----SLTNKPAP---------IVPFYQTEEKLVFEEC 1539
             .:|::...:|..:....|..|....||    :.|.|.:|         .:.:.|.|.:.:.|..
  Fly   145 HEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERT 209

  Fly  1540 SATH--------------------------ARNYNELNASPFPD--------RTRSPAPGPPPNP 1570
            ...|                          |....:|:...:|:        :||||....|...
  Fly   210 PDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQD 274

  Fly  1571 LNAIRAPRMKEPETKSN----ILSVSG---GPRLQTGSITTGQSYQGQLLAHSEQSSQSASQSYN 1628
            .:...|   :...|.:|    .|:::|   ..|....|.:|.||........::....|:...|.
  Fly   275 ADGCEA---RNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYE 336

  Fly  1629 QQPERITEQRVGNLNIQQRE-----QSSQ---LQQQAQSQTQSQTRSQVGNTQIERRRKVTEEFE 1685
            .:.|...:....::.:...:     |||:   |...:.:....:..|::.:..:|.|..::|...
  Fly   337 VKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSEVVN 401

  Fly  1686 RTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQSQSQNQSD---------------------T 1729
            |     .:.:..|....||....|.:.||         .||||                     |
  Fly   402 R-----FLPLFLGGNEDSQLGVSSLTQSQ---------HNQSDPTAGLMDNISDISPINDREELT 452

  Fly  1730 ERRSSYGKTGFVASQAKRLSCMEEEISS--LTSQSQAISARASALGEGCFPNLRSPTFDSKFPL- 1791
            |....|            |..:|...||  ||.:.::    :|.||:    .|..|.|||:..:
  Fly   453 EEVMRY------------LPYLEVNPSSDGLTLKVES----SSLLGK----PLNEPVFDSEDNIV 497

  Fly  1792 ---KPAPAESIVPGYATVP---------------------------AATKMLTAPPPGFLQQQQQ 1826
               ....|...:|.|  ||                           ..|..:|...|
  Fly   498 NDANLHSASHQIPPY--VPDSHDCFAEDCGGDSSSHQVEFEVVRPQTVTMTMTCTLP-------- 552

  Fly  1827 QQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASASASVARSSQSLTQASAITTT--- 1888
                  :.|..|..::.|...|.:...|...| ..|..:.|.|..:..:..|..:|.||.:|
  Fly   553 ------YGGPDAGHTTFQADDFNAIPSAAEDS-ECSILTTSNSPQIGFNGSSFVEADAIGSTCTY 610

  Fly  1889 -----------TNNQATTAYRSSNGSI---TKPNLASRPS 1914
                       |:|....|...:||::   |..:|..:|:
  Fly   611 AQQDYTGSVIETHNDLNYAAHDNNGALLAYTFEDLPPQPT 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	7/70 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900