DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and Synpo2l

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001292067.1	Gene:	Synpo2l / 305675	RGDID:	1565434	Length:	978	Species:	Rattus norvegicus

Alignment Length:	1257	Identity:	256/1257 - (20%)
Similarity:	381/1257 - (30%)	Gaps:	447/1257 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQPQLLQIKLSRFDAQPWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFN 65
            |...:.:|:.|:  ...|||||||||.:..:||.|.|:...|.:.::||:..|.::.||.|...:
  Rat     1 MGAEEEVQVTLA--GGAPWGFRLQGGAEQRKPLQVSKIRRRSQAGRSGLRERDQLLSINGVSCTD 63

  Fly    66 LRHKDAQDIVVRSGNNFVITVQRGGSTWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIG 130
            ..|..|..::..||:..|:||:|        |...|:|..|:...||.::..|....:..    |
  Rat    64 FSHASAMTLIDASGHQLVLTVRR--------VAEEGSVRSPSPGELQMLSPLSPLSPEPP----G 116

  Fly   131 CGYNNAARPFSNGGDGGVKSIVNKQYNTPVGIYSDESIAETLSAQAEVLAGGVLGVNFKKNEKEY 195
            .....|.:|      |.::|                      ...:|...|        :.:.:.
  Rat   117 APVTQAPQP------GSLRS----------------------PPDSEAYYG--------ETDSDV 145

  Fly   196 QGDRSEVLKFLREEETGQSTPAFGNSH----YEHD-----APQQLQQPQQQYNQHQQHYHQQQQQ 251
            .|..:.. |..|....|...|:...:.    |..|     ||.:...|.|..::......::...
  Rat   146 DGPATHE-KPRRTRRRGPPRPSLPGAPPDEVYLSDSPAEPAPVKTGSPSQGDSRVSSPSWEEGSA 209

  Fly   252 QQSSTTRHVSAPVNSPKP-----PSTGGL--PTGQNICTECERLITGVFVRIKDKNLHVECFKCA 309
            .|......:..|....:|     |..|.:  |..:::.|
  Rat   210 LQPPPAEALLLPHGPLRPGPHLIPMVGPVPHPVAEDLTT-------------------------- 248

  Fly   310 TCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIKPNTKLSASTISSALNSHGYG 374
                        .:..|      ||||.:....:..|..|. ..|...:..||.:::|.|.
  Rat   249 ------------TYTQK------AKQAKLQRAESLQEKSVK-EAKTKCRTIASLLTAAPNP---- 290

  Fly   375 GHSNG---YSNGNSTPAPAPVASSQATATVAT------VAPSAATAATAAATPQAATAT-----D 425
             ||.|   :...........:.|..|.|...|      :.|::.:.....|...|.:.|     |
  Rat   291 -HSKGVLMFKKRRQRAKKYTLVSFGAAAGTGTEEEEDGIPPTSESELDEEAFSDARSLTNQSDWD 354

  Fly   426 SPAATASSSDNMSAYVADEPSSIYGQISAESVALAPPPPQPPTAGGGDQPFEY------------ 478
            ||......:...|.....:.|.:.||:|..|             |.|.|.||.
  Rat   355 SPYLDMELARAGSGIAESQSSGLGGQLSEVS-------------GRGVQLFEQQRQRVASSSQEL 406

  Fly   479 ------VTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAAAPKSPVSYP-----PQQQQQSPRP 532
                  ..|.|   :|:|:|.:...         |.|..|..|.||:|.|     |.|...:|.|
  Rat   407 AQVGPAAMLNG---QSLQSPPRAQS---------APPEAAVLPLSPLSAPAASPSPFQDGGAPSP 459

  Fly   533 APG----GQNPYAT-LPRSNVGQQGGEAVEELQPEFEEEDCYEMDIEVALAASRQSQRGSSFTWP 592
            ||.    ...|:.. ||    ||:.|......:|             ||.....::..|:|   |
  Rat   460 APSIFNRSARPFTPGLP----GQRSGTTSVIFRP-------------VAPKKVNEALGGTS---P 504

  Fly   593 PPQDDSHLAPTAAPLYIPPPETQHVVVSNPVQQVPPLPPGGATARLDPQPVVGTSANGAPQWQSY 657
            .|      :|.||.|..|.|......|      ||           :..||.|||::
  Rat   505 AP------SPFAASLQGPTPLPSFTTV------VP-----------NRTPVSGTSSS-------- 538

  Fly   658 SAPQLTTASARQLAEQESSSDSYTSTSTTTTTTSEEYQRMYAAQVQAYQMQEQSGSEFDYQVDYA 722
                           .:.||...|:||
  Rat   539 ---------------TQRSSGPVTATS-------------------------------------- 550

  Fly   723 STQDSVQDYPSGRRSAQECVDSLAVPLSTYKLVDMVREVTPSPVTTPTQTPAPAAPTTRRVVFND 787
                                 ||.:|..:       |.|||.....|...|:.||.|:...:|..
  Rat   551 ---------------------SLYIPAPS-------RPVTPGGAPEPPTPPSAAAMTSTASIFLS 587

  Fly   788 EP-EIKELPQLPAELETIPEASEAVED-------REGLVIE-----QRCQIL---ESERKFQPTP 836
            .| .....|:.|.  ...||.:.|.|.       |.|::.|     .|.|:.   :.|.|..|.|
  Rat   588 TPLRNSARPEAPG--TAAPEPASAREQRISVPAARTGILQEARRRGTRKQMFRPGKEETKNSPNP 650

  Fly   837 EIKIEIAPVRQIPPTKIPNPMPKEWINPMIRVLTTAPEVPFHLVECPFPRPCGDDFEAEAAAAEA 901
            |:...:..:.:.|........|:|      ..|:...|.      |.|.:|.|         ..:
  Rat   651 ELLSLVQNLDEKPRAGGAESGPEE------DALSLGAEA------CNFMQPLG---------GRS 694

  Fly   902 AKT--QEVPEPLPPQVSAAPPATVSVEPSPAPLRESPPRGSR--------LSQAMVTAPEF---- 952
            .||  |..|:..||.....||......|.|.    :|..|||        .|.:||..||.
  Rat   695 YKTLSQVSPKTPPPMAPKTPPPMTPKTPPPV----APKPGSRGLPDGLVNGSTSMVGIPELPRLQ 755

  Fly   953 ----EL---------KFAPPADQGIPL--------PEETEPYMPPPIDTKPYLRED----YRP-K 991
                ||         ::...|..|..|        |..| |.:||.....|.:|..    |.| .
  Rat   756 GRGGELFAKRQSRADRYVVEATPGSSLNPGLRPRSPSPT-PSLPPSWKYSPNIRAPPPIAYNPLL 819

  Fly   992 SPFV-SALTTAPDR-PFEGHFDKDVPIHMIDLPTPKEHLSMCDALCTAPERGYTPLNPENAMHRV 1054
            |||. .|..|.|:: ..:|           ...|||:.:...|.:      .:.|...:.||...
  Rat   820 SPFFPQAARTLPNKAQSQG-----------PRATPKQGIKALDFM------RHQPYQLKTAMFCF 867

  Fly  1055 DEEQKQQELKKREFQVLDHEEELGIRPEPPQSVEYYETRRDQPRKSSAFAAMQAFQPSREPLSSN 1119
            ||.....                .....||::....|.||         .:..|.||:.|||:..
  Rat   868 DEGPSTP----------------ASTSGPPKTARVQEIRR---------FSTPAPQPTAEPLAPT 907

  Fly  1120 TVS-NAGSVADTP--RASIVSA 1138
            .:: .|.:..|.|  ||.:.|:
  Rat   908 VLAPRAATTLDEPIWRAELASS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	28/80 (35%)
		DUF4749	150..>217	CDD:292558	7/66 (11%)
		LIM_ALP_like	282..333	CDD:188746	2/50 (4%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Synpo2l	NP_001292067.1	PDZ_signaling	6..85	CDD:238492	28/80 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810