DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim7

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_038951356.1	Gene:	Pdlim7 / 286908	RGDID:	628769	Length:	464	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	141/476 - (29%)
Similarity:	206/476 - (43%)	Gaps:	96/476 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1748 LSCMEEEISSLTSQSQAISA--RASALGEGCFPNL-RSPTFDSKFPLKPAPAESIVPGYATVPAA 1809
            ||...|...|||.    |.|  :..|.||.....| |:....|| |.|.....:..|.|...|:|
  Rat    51 LSIDGENAGSLTH----IEAQNKIRACGERLSLGLSRAQPAQSK-PQKALTPPADPPRYTFAPSA 110

  Fly  1810 TKMLT-----APPPGFLQQQQQQQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSSSSASASAS 1869
            :...|     ||||                                    |.|:||.:......|
  Rat   111 SLNKTARPFGAPPP------------------------------------TDSALSQNGCRPLTS 139

  Fly  1870 ASVARSSQSLTQASAITTTTNNQATTAYRSSNGS-----------ITKPNLASRPS---IASITA 1920
            ..:.|  |.:..||......|   |..:|...|:           :|.......|.   :...:.
  Rat   140 QQLLR--QLVPDASKQRLMEN---TEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQ 199

  Fly  1921 PGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPG 1985
            .....||||. |..|.::   :..|..| |..:....|..|.....:.||.:...|..:  :.|
  Rat   200 VPRTEAPAPA-STIPQES---WPGPTTP-SPTSRPPWAVDPAFAERYAPDKTSTVLTRH--SQP- 256

  Fly  1986 AGGKSAGAFGATSAPKRGR-GILNKAAGPGV-------RIPLCNSCNVQIRGPFITALGRIWCPD 2042
                      ||..|.:.| .|:..|||.|.       :.|:|:.|:..|||.::.|||..:.|:
  Rat   257 ----------ATPTPLQNRTSIVQAAAGGGTGGGSNNGKTPVCHQCHKIIRGRYLVALGHAYHPE 311

  Fly  2043 HFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTC 2107
            .|:|  ..|.:.|::.||.||||.::|..|::...||:|:||..||.|:.::|:...:|..||||
  Rat   312 EFVC--SQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPSCAKCKKKITGEIMHALKMTWHVPCFTC 374

  Fly  2108 GQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCK 2172
            ..|.....||.|::|:|..|||.|:.::|.|||..|.|.::||||::|||..::|..||.|..|:
  Rat   375 AACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQ 439

  Fly  2173 QNLEGQSFYNKGGRPFCKNHA 2193
            .||||::||:|..:|.||:||
  Rat   440 INLEGKTFYSKKDKPLCKSHA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	20/52 (38%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	25/52 (48%)
Pdlim7	XP_038951356.1	PDZ_signaling	5..79	CDD:238492	11/31 (35%)
		PHA03247	<11..261	CDD:223021	58/273 (21%)
		DUF4749	<163..192	CDD:406377	4/28 (14%)
		LIM1_Enigma	289..340	CDD:188836	20/52 (38%)
		LIM2_Enigma	348..399	CDD:188840	21/50 (42%)
		LIM3_Enigma	407..461	CDD:188842	27/54 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343452
Domainoid	1	1.000	77	1.000	Domainoid score	I8642
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013114at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm45363
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810