DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and PDLIM3

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_055291.2	Gene:	PDLIM3 / 27295	HGNCID:	20767	Length:	364	Species:	Homo sapiens

Alignment Length:	391	Identity:	112/391 - (28%)
Similarity:	160/391 - (40%)	Gaps:	93/391 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            ||||||.||.||.|||::.::..||.:..|.|.|||.::.|:.....::.|.||||.:..:.:..
Human    12 PWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAAAHQL 76

  Fly    83 VITVQRGGS-TWRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYNNAARPF-----S 141
            .:.:.||.: .|.|.|:..|..    .|:     |.:|..:.||..:....:|...:||     |
Human    77 CLKIDRGETHLWSPQVSEDGKA----HPF-----KINLESEPQDGNYFEHKHNIRPKPFVIPGRS 132

  Fly   142 NG---------GDG-----------------------------------GVKSIVNKQYNTPVGI 162
            :|         |.|                                   ||| ||:.|:|||:.:
Human   133 SGCSTPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKLAPNIPLEMELPGVK-IVHAQFNTPMQL 196

  Fly   163 YSDESIAETLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDA 227
            |||::|.|||..|.....|...                     |..|.|....|........||.
Human   197 YSDDNIMETLQGQVSTALGETP---------------------LMSEPTASVPPESDVYRMLHDN 240

  Fly   228 PQQLQQPQQQYN-QHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGG--LPTGQNICTECERLI 289
            ..:..||:|..: :..|.........:.:.||.|.|||......|.|.  :|    :|.:|...|
Human   241 RNEPTQPRQSGSFRVLQGMVDDGSDDRPAGTRSVRAPVTKVHGGSGGAQRMP----LCDKCGSGI 301

  Fly   290 TGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQAAINNPPTGTEGYVPVPIK 354
            .|..|:.:||..|.|||.||.|..:||.:||:....:|||:.||:  |...||   |||..|.:.
Human   302 VGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCETHAR--ARTKPP---EGYDTVTLY 361

  Fly   355 P 355
            |
Human   362 P 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	26/68 (38%)
		DUF4749	150..>217	CDD:292558	18/66 (27%)
		LIM_ALP_like	282..333	CDD:188746	21/50 (42%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
PDLIM3	NP_055291.2	PDZ_signaling	2..80	CDD:238492	26/67 (39%)
		DUF4749	184..263	CDD:374237	26/100 (26%)
		LIM_ALP	294..346	CDD:188834	22/51 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10447
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940