DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and LHX6

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_011516823.1	Gene:	LHX6 / 26468	HGNCID:	21735	Length:	407	Species:	Homo sapiens

Alignment Length:	297	Identity:	62/297 - (20%)
Similarity:	94/297 - (31%)	Gaps:	124/297 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1913 PSIASITA-PGSASAPAPVPSAAPTK---ATAPFKAPIVPKS---VIANAV-------NAAAPPA 1963
            |:...:.| |||.       ..|.|:   .|||   |.:.:|   .:|.|:       :...|..
Human    24 PATDQVMAQPGSG-------CKATTRCLEGTAP---PAMAQSDAEALAGALDKDEGQASPCTPST 78

  Fly  1964 PAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIR 2028
            |:|..|              |.|         |:|.|..|:.|             |:||.::|.
Human    79 PSVCSP--------------PSA---------ASSVPSAGKNI-------------CSSCGLEIL 107

  Fly  2029 GPFITALGR-IWCPDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDC 2092
            ..::..:.. ||   |..|:.                                ||.|...::..
Human   108 DRYLLKVNNLIW---HVRCLE--------------------------------CSVCRTSLRQQ- 136

  Fly  2093 LNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEAL 2157
                           ..|         ::::...:|:.|:...|.|||..||..:.|.| ||...
Human   137 ---------------NSC---------YIKNKEIFCKMDYFSRFGTKCARCGRQIYASD-WVRRA 176

  Fly  2158 NHN-YHSQCFNCTFCKQNLE-GQSFYNKGGRPFCKNH 2192
            ..| ||..||.|..||:.|. |:.|.....:..|:.|
Human   177 RGNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIH 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	8/53 (15%)
		LIM	2081..2132	CDD:259829	5/50 (10%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	20/55 (36%)
LHX6	XP_011516823.1	LIM1_Lhx6	99..152	CDD:188766	13/112 (12%)
		LIM2_Lhx6	160..214	CDD:188768	20/55 (36%)
		Homeobox	252..304	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940