DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Tgfb1i1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_036008777.1	Gene:	Tgfb1i1 / 21804	MGIID:	102784	Length:	496	Species:	Mus musculus

Alignment Length:	464	Identity:	124/464 - (26%)
Similarity:	186/464 - (40%)	Gaps:	83/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1765 ISAR--ASALGEGCFPN-LRSPTFDSKFPLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQ 1826
            :|.|  ||..|.|...| |.||         |:|: |...|:...|...|:..:.||
Mouse    15 VSQRVPASIHGHGPASNSLTSP---------PSPS-SAPTGHGPRPTLPKLSASAPP-------- 61

  Fly  1827 QQQRSAFSGYQATTSSVQQSSFASSSKATTSSLSS--------------SSASASASASVARSSQ 1877
                     ::..|.|.:.|..........|::..              ||:|......:....:
Mouse    62 ---------WRTWTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDR 117

  Fly  1878 SLTQASAITTTTNNQATTAYRSS---NGSITKPNLASRPSIASITAPGSA-------SAPAPVPS 1932
            .|.:.:|......::..:.:.||   .|. .|.:.:...|..::.| ||.       |.|:|.|
Mouse   118 LLQELNATQFNITDEIMSQFPSSKMAEGE-EKEDQSEDKSSPTVLA-GSEVIHGVLHSPPSPFP- 179

  Fly  1933 AAPTKATAPFKAPIVPKSV-------IANAVNAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKS 1990
             ||:|.:|......:.:.:       :.|.:.|:.||.|....|      ......:.||...|.
Mouse   180 -APSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASP------TREGCPSPPGQTSKG 237

  Fly  1991 A--GAFGATSAPKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRR 2053
            :  ...|...:....||:..:|.|      ||.|||..|.|..:|||||.|.|:||:|  ..|..
Mouse   238 SLDTMLGLLQSDLSRRGVPTQAKG------LCGSCNKPIAGQVVTALGRAWHPEHFLC--SGCST 294

  Fly  2054 PLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRP 2118
            .|....|.|:.|..:|..|:.:..:|.|..|...|:...:.|:|.|:|||.|.|..||:.||...
Mouse   295 TLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEG 359

  Fly  2119 FFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNK 2183
            |...:|..||..|:.:||..:|..|..|:.  |.::.||:..:|..||.|..|.....|.||:..
Mouse   360 FHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALWHPDCFVCRECLAPFSGGSFFEH 422

  Fly  2184 GGRPFCKNH 2192
            .|||.|:||
Mouse   423 EGRPLCENH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	22/52 (42%)
		LIM	2081..2132	CDD:259829	19/50 (38%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	20/53 (38%)
Tgfb1i1	XP_036008777.1	Paxillin	4..>128	CDD:397550	27/139 (19%)
		LIM1_Paxillin_like	263..315	CDD:259830	23/53 (43%)
		LIM2_Paxillin_like	322..373	CDD:188723	19/50 (38%)
		LIM	381..433	CDD:413332	20/53 (38%)
		LIM4_Leupaxin	440..491	CDD:188796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910