DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and Pdlim2

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001240665.1	Gene:	Pdlim2 / 213019	MGIID:	2384850	Length:	349	Species:	Mus musculus

Alignment Length:	369	Identity:	92/369 - (24%)
Similarity:	154/369 - (41%)	Gaps:	94/369 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQDIVVRSGNNF 82
            |||||:.||.||..|::|.||.....:|.|.|:|||.:|.||.....|:.|.:||..:.:|.:..
Mouse    12 PWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGQSAENMLHAEAQSKIRQSASPL 76

  Fly    83 VITVQRG-----------GS----------TWRPH-----------VTPTGNVPQPNSPYLQTVT 115
            .:.:.|.           ||          :.|.|           .:|....|:|.||:.....
Mouse    77 RLQLDRSQTASPGQTNGEGSLEVLATRFQGSLRTHRDSQSSQRSACFSPVSLSPRPCSPFSTPPP 141

  Fly   116 KTSLAHKQQDSQHIGCGYNN--------AARPFSNGGDGGVKSIVNKQ--YNTPVGIYSDESIAE 170
            .:.:|..::|.  |||.:.:        ||...:..|..     .::|  :::|    ||.::..
Mouse   142 TSPVALSKEDM--IGCSFQSLTHSPGLAAAHHLTYPGHP-----TSQQAGHSSP----SDSAVRV 195

  Fly   171 TLSAQAEVLAGGVLGVNFKKNEKEYQGDRSEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQ 235
            .|.:     .|......|...:.|   :.|||.|.|:|...|::.|...:|.      :.||:
Mouse   196 LLHS-----PGRPSSPRFSSLDLE---EDSEVFKMLQENRQGRAAPRQSSSF------RLLQE-- 244

  Fly   236 QQYNQHQQHYHQQQQQQQSSTTRHVSAPVNSPKPPSTGGLPTGQ--------NICTECERLITGV 292
                       ..:.:::..|...|.:.::     |...|||.:        :.|.:|...|:..
Mouse   245 -----------ALEAEERGGTPAFVPSSLS-----SQASLPTSRALATPPKLHTCEKCSVNISNQ 293

  Fly   293 FVRIKD-KNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHAKQ 335
            .|||:: :..|..|:.||.||.:||.:|::...|:|||:.||:|
Mouse   294 AVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	27/68 (40%)
		DUF4749	150..>217	CDD:292558	15/68 (22%)
		LIM_ALP_like	282..333	CDD:188746	19/51 (37%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Pdlim2	NP_001240665.1	PDZ_signaling	9..80	CDD:238492	27/67 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..147		10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..212		9/56 (16%)
		DUF4749	<198..252	CDD:406377	14/80 (18%)
		LIM_Mystique	283..335	CDD:188833	19/51 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839628
Domainoid	1	1.000	61	1.000	Domainoid score	I10388
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840