DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp52 and lim-4

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_508669.1	Gene:	lim-4 / 180672	WormBaseID:	WBGene00002987	Length:	355	Species:	Caenorhabditis elegans

Alignment Length:	306	Identity:	67/306 - (21%)
Similarity:	102/306 - (33%)	Gaps:	99/306 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1892 QATTAYRSSNGSITKPNLASRPSIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAV 1956
            :.:||...|:.|:|.|.:....|..|:|.....|..:.:....|..|...|.:.......|::|:
Worm    10 KTSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFSSSDESSVYISSAL 74

  Fly  1957 NAAAPPAPAVFPPDLSDLNLNSNVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGPGVRIPLCN 2021
            ..    |...|.||       .|:...|.|                             .|.:|.
Worm    75 RL----ADYAFTPD-------DNIRIKPDA-----------------------------VIVICT 99

  Fly  2022 SCNVQIRGPFITAL-GRIWCPDHFICVN-GNCRRPLQDIGFVEEKGDLYCEYC-FEKYLAPTCSK 2083
            .|..||:..|..:: ||.:   |..|:. ..|..||.:..|.::| ..||:.| |..::..|.|.
Worm   100 QCQHQIQDKFFLSIDGRNY---HENCLQCSTCENPLSNKCFYKDK-TFYCKGCYFRTHVTSTASS 160

  Fly  2084 CAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVE 2148
            |             :...|                                    ||.:|...::
Worm   161 C-------------RELGP------------------------------------KCASCDRTIQ 176

  Fly  2149 AGDRWV-EALNHNYHSQCFNCTFCKQNLE-GQSFYNKGGRPFCKNH 2192
            |.| || .|.|:.||..||:|..||:.|. |:.:..:.|...||.|
Worm   177 ATD-WVRRARNYVYHLACFSCNQCKRQLSTGEEYALQEGNLLCKQH 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	17/55 (31%)
		LIM	2081..2132	CDD:259829	3/50 (6%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	21/55 (38%)
lim-4	NP_508669.1	LIM	98..153	CDD:278823	18/58 (31%)
		LIM2_AWH	168..222	CDD:188765	21/55 (38%)
		HOX	239..295	CDD:197696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940