DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp52 and alp-1

DIOPT Version :9

Sequence 1:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	2298	Identity:	490/2298 - (21%)
Similarity:	725/2298 - (31%)	Gaps:	992/2298 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IKLSRFDAQ-PWGFRLQGGTDFAQPLLVQKVNAGSLSEQAGLQPGDAVVKINDVDVFNLRHKDAQ 72
            ::::|.|.: ||||.:....|.|  :|:..|..|||:::|||:.||.|.::.|:|..::...|..
Worm     6 VRMARSDRRTPWGFGVTEAPDGA--VLIVNVIGGSLADRAGLRNGDVVDRLEDLDNLDINAVDRL 68

  Fly    73 DIVVRSGNNFVITVQRGGST---WRPHVTPTGNVPQPNSPYLQTVTKTSLAHKQQDSQHIGCGYN 134
            .:........::|.|..|:.   |||.||......|..:||...:..:|.....|       |:|
Worm    69 LVTAHEKIELIVTRQPSGAATRIWRPEVTENTGPGQDQTPYRVNLQHSSDTRPPQ-------GFN 126

  Fly   135 NAARPFSNGGDGGVKSIVNKQYNTPVGIYSDESIAETLSAQAEVLA--GGVLGVNFKKNEKEYQG 197
            |:|.||..  |..||   :.|||:|:|||||:|.||....|.:.|.  .|......:::|..|.
Worm   127 NSALPFET--DQRVK---HMQYNSPLGIYSDKSAAEQYVQQTQGLGDNSGARAAAQRQDEPAYL- 185

  Fly   198 DRSEVLKFLREEETGQSTPAFGNSHYEHDAPQQLQQPQQQYNQHQQHYHQQQQQQQSSTTRHVSA 262
             |||.|:.|:|:|.|.:..| |.:...|
Worm   186 -RSETLRLLKEQEHGSAGGA-GTTLSNH------------------------------------- 211

  Fly   263 PVNSPKPPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKL 327
                   |:..|||    :|..|.|.|.||..|...||||.:|..|||||.||:|.|::...:|.
Worm   212 -------PNPSGLP----VCFMCTRPILGVMARAAGKNLHGDCLSCATCGNSLRNVGHHFIEDKF 265

  Fly   328 YCDIHAKQAAINNPPTGTEGYVPVPIKPNTKLSASTISSALNSHGYGGHSNGYSNGNSTPAPAPV 392
            |||||..|......|         .:.||..:.:|
Worm   266 YCDIHGTQRKHGGRP---------GMDPNIFVKSS------------------------------ 291

  Fly   393 ASSQATATVATVAPSAATAATAAATPQAATATDSPAATASSSDNMSAYVADEPSSIYGQI-SAES 456
                         |:||         |.....|||.|         ||        :.|: :|..
Worm   292 -------------PTAA---------QPVHIQDSPRA---------AY--------HPQVNTARP 317

  Fly   457 VALAPPPPQPPTAGGGDQPFEYVTLTGNVIRSVQAPGKGACPSYKVNQGYARPFGAAAPKSPVSY 521
            |:::|    .|:||.......|.|   ...:.:.:||:...|:        ..|||...|| |:|
Worm   318 VSVSP----APSAGSKTVTTHYHT---PKTQGILSPGQRGVPT--------AAFGADLSKS-VTY 366

  Fly   522 PPQQQQQSPRPAPGGQNPYATLPRSNVGQQGGEAVEELQPEFEEEDCYEMDIEVALAASRQSQRG 586
                        .||..|..|...||          .|.|                |.|:.|.:.
Worm   367 ------------GGGVGPGGTHYDSN----------RLSP----------------APSQYSTQS 393

  Fly   587 SSFTWPPPQDDSHLAPTAAPLYIPPPETQHVVVSNPVQQVPPLPPGGATARLDPQPVVGTSANGA 651
            .:      |...|.             .|||     ||..||:|.       :|.|     :|
Worm   394 RN------QSQQHY-------------QQHV-----VQAPPPVPS-------NPPP-----SN-- 420

  Fly   652 PQWQSYSAPQLTTASARQLAEQESSSDSYTSTSTTTTTTSEEYQRMYAAQVQAYQMQEQSGSEFD 716
                                ||:|.|                       :||
Worm   421 --------------------EQQSQS-----------------------RVQ------------- 429

  Fly   717 YQVDYASTQDSVQDYPSGRRSAQECVDSLAVPLSTYKLVDMVREVTPSPVTTPTQTPAPAAPTTR 781
                  :..|||:...|.|||.:                            :|.|.|.||.|||.
Worm   430 ------NLPDSVRSAVSPRRSGK----------------------------SPRQWPPPAMPTTN 460

  Fly   782 R--------------VVFND---------------EPEIKELPQLPA---------ELETIPEAS 808
            |              |.:.:               ||::|:.|:...         ..|.:.:|.
Worm   461 RYWQIDPADALKKEKVNYGEDLVALIKEVEQSKEKEPKVKKEPKKGTRGARRASNISKEQVQQAF 525

  Fly   809 EAVEDREGLVIEQRCQILESERKFQPTPEIKIEIAPVRQIPPTKIPNPMPKEWINPMIRVLTTAP 873
            |....|     .:|.:|.:.|::.:|.||:|:|: ||.   |..:|...|.|
Worm   526 EEQRKR-----TERKEIKKLEKEIKPKPELKVEV-PVE---PLVVPTSKPLE------------- 568

  Fly   874 EVPFHLVECPFPRPCGDDFEAEAAAAEAAKTQEVPEPL-PPQVSAAPPATVSVEP---SPAPLRE 934
                        .||                   ||.| ||:::.....||...|   ||:|
Worm   569 ------------EPC-------------------PEALPPPKINDGIHWTVIHSPVLRSPSP--- 599

  Fly   935 SPPRGSRLSQAMVTAPEFELKFAPPADQGI--PLPEETEPYMPPPID-TKPYLREDYRPKSPFVS 996
                      |.||:     :.|.|...|:  |:|.    |...||. :|....:.:||.|..
Worm   600 ----------AKVTS-----EAAIPESNGVVKPIPS----YASQPIGISKTSTPQPFRPGSQV-- 643

  Fly   997 ALTTAPDRPFEGHFDKDVPIHMIDLPTPKEHLSMCDALCTAPERGYTPLNPENAMHRVDEEQKQQ 1061
                  :||   |: ..|.:..:..|.|                  .|.:|:::
Worm   644 ------ERP---HY-SSVGLKDVHAPVP------------------LPRSPQHS----------- 669

  Fly  1062 ELKKREFQVLDHEEELGIRPEPPQSVEYYETRRDQPRKSSAFAAMQAFQPSREPLSSNTVSNAGS 1126
                                  ||.|:.|..|
Worm   670 ----------------------PQPVQSYIVR--------------------------------- 679

  Fly  1127 VADTPRASIVSALKEETDLEYQKYLKAQQRNQKRLDYFHQKEEELSGLQGQQLTQLQRELSNQQQ 1191
                                                                         :...
Worm   680 -------------------------------------------------------------SSDA 683

  Fly  1192 NLLSQQQLQQSKLLQLQQCVQSQELQQQVQHLTQKSQQQPPQANQQQQQQQQQRGTQQQQHSQVT 1256
            |:.:...||.                                             |..:|:::..
Worm   684 NVTTSTNLQT---------------------------------------------TVTRQYTEND 703

  Fly  1257 QRTQQQQQQVPQQVTQQQQQEHSLLSQTTLAETQTLQANAQSQSSASYSSKATACSNSSSTVPPA 1321
            .::|..||..|..:.          |.|:...|..|..:.:.:.|...|            ||..
Worm   704 NKSQFLQQPHPDTID----------SSTSPIPTIRLNRHTKPEPSTPLS------------VPTV 746

  Fly  1322 NTSTAFAPAPAPAPTSIPVRPSAIAVQSSYCSSQFDVHELIEETAEELEHSEVLFPPPSPLSHLT 1386
            :.:..   |.:|...:.|.||...:|.:| .:|...:||...:..:|
Worm   747 SINDI---ATSPIKITEPSRPWRASVSNS-ATSPIKIHESRVQPVDE------------------ 789

  Fly  1387 KQGKAVQSGLHKADSIPKYQRNWTVLPTQSPIRTPEPQELRENVPLAFVDAPKAPVTSDSSTVHR 1451
                  ..|||:.:.                                     ||.:.:.:..:|.
Worm   790 ------SRGLHRHEE-------------------------------------KAQIETSTIKIHE 811

  Fly  1452 P------IAQVAAPTTVVAPSREREKERRPQLSVPIIVEDRSGPVTMAFQPLDELVRPDQALTPT 1510
            |      :.:..|..|..||:..:..: .|:::|.|  .:.:||                  :||
Worm   812 PSSPPPSVHKFGAVNTRAAPAPVQFMQ-TPRIAVKI--HEPTGP------------------SPT 855

  Fly  1511 RPYTPSLTNKPAP--------------IVPFYQ-----TEEKLVFEECSATHARNYNELNASPFP 1556
            .|.|||...|..|              ::|.::     .:|..:..|||
Worm   856 PPSTPSHPIKRDPKHFKKVDFSKTSPTVIPEWKDSADIVDESDILTECS---------------- 904

  Fly  1557 DRTRSPAPGPPPNPLNAIRAPRMKEPETKSNILSVSGGPRLQTGSITTGQSYQG---QLLAHSEQ 1618
                                   :|.::.|.:.:.               :|.|   :::.::..
Worm   905 -----------------------REDDSISFLKAA---------------TYDGDESEMIDNNID 931

  Fly  1619 SSQSASQSYN---------QQPERITEQRVGNLNIQQREQSSQLQQQAQSQTQSQTRSQVGNTQI 1674
            :....:.:::         |..|||  :.||....:..|...|.:|:|......       :.|.
Worm   932 NKSDITSTFDIEEEEVDVVQDRERI--RVVGRKGGEGGEAEKQWRQRAMELLDD-------DAQT 987

  Fly  1675 ERRRKVTEEF-ERTQSAKTIEIRTGSQSVSQSKAQSQSISQAQTQAQS-------QSQNQSDTER 1731
            ||..::.... ||.|..:.:|.....:::.........:.|.|||..:       ..||     .
Worm   988 ERDLRIVAALNERLQGLREMEDDDRVRAIECIARHQSELEQTQTQLSTLLESAIVYLQN-----L 1047

  Fly  1732 RSSYGKTGFVASQAKRLSCM-------EEEISSLTSQSQAISARASALGEGCFPNLRSPTFDSKF 1789
            |.....|..:.:.||.|..:       |:.::.:..:..........||:|         .||..
Worm  1048 RPELELTEPIDNDAKSLETVKFEPTRAEQRVNEIRKKVLEDLEHLPILGDG---------MDSVP 1103

  Fly  1790 PLKPAPAESIVPGYATVPAATKMLTAPPPGFLQQQQQQQQRSAFSGYQATTSSVQQS------SF 1848
            |  |.|...:.|..:..|.|.:.   |.|                   |..|.|.||      .|
Worm  1104 P--PPPERKVFPFQSYQPIAPQF---PVP-------------------AAESPVTQSLHDVLDEF 1144

  Fly  1849 ASSSKATTSSLSSSSASASASASVARSSQSLTQASAITTTTNNQATTAYRSSNGSITKPNLASRP 1913
            .|..|.|.:...:.|:..:|..|....:..|.|   :....|.:|    ..||||....|
Worm  1145 YSLRKPTPTQNVAQSSDTTAEDSRNFLASRLGQ---VMIDENKKA----GGSNGSSQHHN----- 1197

  Fly  1914 SIASITAPGSASAPAPVPSAAPTKATAPFKAPIVPKSVIANAVNAAAPPAPAVFPPDLSDLNLNS 1978
                    ...|:.........|..|.|.:             |..||
Worm  1198 --------QQGSSYTKTSFERTTTETRPQQ-------------NTGAP----------------- 1224

  Fly  1979 NVDNSPGAGGKSAGAFGATSAPKRGRGILNKAAGP---GVRIPLCNSCNVQIRGPFITALGRIWC 2040
                       .||.|       ||.|.|......   |.|.|.|.||..||||.|:.|.|:.||
Worm  1225 -----------RAGDF-------RGTGHLTTTTTTQQNGGRAPFCESCKQQIRGAFVLATGKSWC 1271

  Fly  2041 PDHFICVNGNCRRPLQDIGFVEEKGDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECF 2105
            |:||:|.|.:|||.|.:.|||||.|..:||.|||:::||.|:||:..|..|||||:.|.:||.||
Worm  1272 PEHFVCANSSCRRRLLECGFVEEDGQKFCESCFEQHIAPRCNKCSKPIISDCLNALQKKWHPTCF 1336

  Fly  2106 TCGQCGKIFGNRPFFLEDGNAYCEADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTF 2170
            ||..|.|.|||..|:||.|..|||.|||.||||||.:|.:|:||||||||||.:.:||.||.|..
Worm  1337 TCAHCQKPFGNSAFYLEQGLPYCEQDWNALFTTKCVSCRYPIEAGDRWVEALGNAFHSNCFTCAR 1401

  Fly  2171 CKQNLEGQSFYNKGGRPFCKNHA 2193
            |..||||:||:.|.|:|||:.||
Worm  1402 CNHNLEGESFFAKNGQPFCRLHA 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	23/78 (29%)
		DUF4749	150..>217	CDD:292558	25/68 (37%)
		LIM_ALP_like	282..333	CDD:188746	26/50 (52%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839	29/52 (56%)
		LIM	2081..2132	CDD:259829	28/50 (56%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	30/52 (58%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492	22/75 (29%)
		DUF4749	137..>197	CDD:292558	25/64 (39%)
		ZM	137..162	CDD:128974	14/27 (52%)
		LIM_ALP_like	220..271	CDD:188746	26/50 (52%)
		LIM1_Enigma_like_1	1251..1304	CDD:188839	29/52 (56%)
		LIM	1312..1363	CDD:295319	28/50 (56%)
		LIM3_Enigma_like_1	1371..1424	CDD:188845	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157727
Domainoid	1	1.000	83	1.000	Domainoid score	I5354
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1092
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		oto17825
orthoMCL	1	0.900	-	-		OOG6_109269
Panther	1	1.100	-	-	LDO	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	1	1.000	-	-		X13649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.010